Found 4 results

Search term: MF = 'C_{30}H_{53}N_{5}O_{8}'
ChemSpider 2D Image | N-Acetyl-N-methyl-L-isoleucyl-L-isoleucyl-L-threonyl-N-{2-[(2R)-2-methyl-2-oxiranyl]-2-oxoethyl}-L-leucinamide | C30H53N5O8

N-Acetyl-N-methyl-L-isoleucyl-L-isoleucyl-L-threonyl-N-{2-[(2R)-2-methyl-2-oxiranyl]-2-oxoethyl}-L-leucinamide

  • Molecular FormulaC30H53N5O8
  • Average mass611.771 Da
  • Monoisotopic mass611.389404 Da
  • ChemSpider ID110196

  • defined stereocentres - 8 of 8 defined stereocentres

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

L-Leucinamide, N-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-L-threonyl-N-[2-[(2R)-2-methyloxiranyl]-2-oxoethyl]- [ACD/Index Name]
N-Acetyl-N-methyl-L-isoleucyl-L-isoleucyl-L-threonyl-N-{2-[(2R)-2-methyl-2-oxiranyl]-2-oxoethyl}-L-leucinamid [German] [ACD/IUPAC Name]
N-Acetyl-N-methyl-L-isoleucyl-L-isoleucyl-L-threonyl-N-{2-[(2R)-2-methyl-2-oxiranyl]-2-oxoethyl}-L-leucinamide [ACD/IUPAC Name]
N-Acétyl-N-méthyl-L-isoleucyl-L-isoleucyl-L-thréonyl-N-{2-[(2R)-2-méthyl-2-oxiranyl]-2-oxoéthyl}-L-leucinamide [French] [ACD/IUPAC Name]

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

AIDS010837 [DBID]
AIDS-010837 [DBID]
  • Miscellaneous

    • Bio Activity:

      Antibiotic. Potent anticancer compound. Cell permeable, potent, selective and irreversible 20S proteasome inhibitor. Predominantly inhibits the chymotrypsin-like (CTRL) activity of the proteasome. Exhibits lower level inhibition of proteasome trypsin-like and caspase-like activitives (100 and 1,000-fold slower rates respectively). Anti-inflammatory. Antimicrobial and antimalarial. Anti-parasitic. Stimulates bone formation by inhibiting osteoblast proteasome activity. Induces Parkinson's-like symptoms in rats. The ubiquitin-proteasome system (UPS) and autophagy serve as two complementary, reciprocally regulated protein degradation systems. Blockade of UPS by Epoxomicin activates autophagy. Hello Bio HB3890
      Biochemicals & small molecules/Antagonists & inhibitors Hello Bio HB3890
      Enzymes/Protease / Peptidase/Proteasome Hello Bio HB3890
      Potent, selective and irreversible 20S proteasome inhibitor Hello Bio HB3890

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.1±0.1 g/cm3
Boiling Point: 891.1±65.0 °C at 760 mmHg
Vapour Pressure: 0.0±0.6 mmHg at 25°C
Enthalpy of Vaporization: 147.1±6.0 kJ/mol
Flash Point: 492.7±34.3 °C
Index of Refraction: 1.509
Molar Refractivity: 159.9±0.3 cm3
#H bond acceptors: 13
#H bond donors: 5
#Freely Rotating Bonds: 18
#Rule of 5 Violations: 3
ACD/LogP: 2.70
ACD/LogD (pH 5.5): 1.61
ACD/BCF (pH 5.5): 9.78
ACD/KOC (pH 5.5): 177.92
ACD/LogD (pH 7.4): 1.61
ACD/BCF (pH 7.4): 9.78
ACD/KOC (pH 7.4): 177.92
Polar Surface Area: 187 Å2
Polarizability: 63.4±0.5 10-24cm3
Surface Tension: 45.5±3.0 dyne/cm
Molar Volume: 535.3±3.0 cm3

Click to predict properties on the Chemicalize site


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