ChemSpider 2D Image | Eltoprazine hydrochloride | C12H17ClN2O2

Eltoprazine hydrochloride

  • Molecular FormulaC12H17ClN2O2
  • Average mass256.729 Da
  • Monoisotopic mass256.097870 Da
  • ChemSpider ID2290862

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1-(2,3-Dihydro-1,4-benzodioxin-5-yl)-piperazine hydrochloride
1-(2,3-Dihydro-1,4-benzodioxin-5-yl)piperazine hydrochloride (1:1) [ACD/IUPAC Name]
1-(2,3-Dihydro-1,4-benzodioxin-5-yl)pipérazine, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
1-(2,3-Dihydro-1,4-benzodioxin-5-yl)piperazinhydrochlorid (1:1) [German] [ACD/IUPAC Name]
Eltoprazine (hydrochloride)
Eltoprazine hydrochloride
MFCD06245586 [MDL number]
Piperazine, 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-, hydrochloride (1:1) [ACD/Index Name]
[98206-09-8] [RN]
[98224-03-4] [RN]
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

5275JY4PKD [DBID]
CCRIS 4693 [DBID]
DU-28853 [DBID]
RU-24969 [DBID]
UNII:5275JY4PKD [DBID]
UNII-5275JY4PKD [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      5-HT Receptor MedChem Express HY-16687A
      5-HT Receptors Tocris Bioscience 1860
      5-HT1 and 5-HT2C receptor partial agonist (Ki values are 40, 52 and 81 nM for 5-HT1A, 5-HT1B and 5-HT2C receptors respectively). Reduces 5-HIAA levels in the striatum and exhibits antiaggressive behav ior in vivo. Tocris Bioscience 1860
      5-HT1 and 5-HT2C receptor partial agonist (Ki values are 40, 52 and 81 nM for 5-HT1A, 5-HT1B and 5-HT2C receptors respectively). Reduces 5-HIAA levels in the striatum and exhibits antiaggressive behavior in vivo. Tocris Bioscience 1860
      5-HT1 receptor agonist/partial agonist Tocris Bioscience 1860
      5-HT1 Receptors Tocris Bioscience 1860
      7-TM Receptors Tocris Bioscience 1860
      Eltoprazine(DU28853) is a serenic or antiaggressive agent which as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor. MedChem Express
      Eltoprazine(DU28853) is a serenic or antiaggressive agent which as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor.; IC50 value:; Target: 5-HT1A/1B agonist; 5-HT2C antagonist; in vitro: The binding of [3H]eltoprazine to whole tissue sections was saturable and revealed an apparent dissociation constant (Kd) of 11 nM. MedChem Express HY-16687A
      Eltoprazine(DU28853) is a serenic or antiaggressive agent which as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor.;IC50 value:;Target: 5-HT1A/1B agonist; 5-HT2C antagonist;In vitro: The binding of [3H]eltoprazine to whole tissue sections was saturable and revealed an apparent dissociation constant (Kd) of 11 nM. Specific [3H]eltoprazine binding was completely displaced by 5-HT; conversely, unlabelled eltoprazine reduced [3H]5-HT binding to the levels of non-specific binding [1]. Eltoprazine evoked membrane changes that were similar to but much weaker than those induced by 5HT. Both the 5HT- and eltoprazine-evoked membrane hyperpolarizations were largely suppressed in the presence of spiperone [2].;In vivo: eltoprazine is extremely effective in suppressing dyskinesia in experimental models, although this effect was accompanied by a partial worsening of the therapeutic effect of l-dopa. Interestingly, eltoprazine was found to (synergistical MedChem Express HY-16687A
      GPCR/G protein MedChem Express HY-16687A
      GPCR/G protein; Neuronal Signaling; MedChem Express HY-16687A

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

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