ChemSpider 2D Image | IM-12 | C22H20FN3O2

IM-12

  • Molecular FormulaC22H20FN3O2
  • Average mass377.411 Da
  • Monoisotopic mass377.153961 Da
  • ChemSpider ID26350622

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1129669-05-1 [RN]
1H-Pyrrole-2,5-dione, 3-[[2-(4-fluorophenyl)ethyl]amino]-1-methyl-4-(2-methyl-1H-indol-3-yl)- [ACD/Index Name]
3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
3-{[2-(4-Fluorophenyl)ethyl]amino}-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione [ACD/IUPAC Name]
3-{[2-(4-Fluorophényl)éthyl]amino}-1-méthyl-4-(2-méthyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione [French] [ACD/IUPAC Name]
3-{[2-(4-fluorophenyl)ethyl]amino}-1-methyl-4-(2-methyl-1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione
3-{[2-(4-fluorophenyl)ethyl]amino}-1-methyl-4-(2-methyl-1H-indol-3-yl)pyrrole-2,5-dione
3-{[2-(4-Fluorphenyl)ethyl]amino}-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrol-2,5-dion [German] [ACD/IUPAC Name]
IM-12
MFCD20527313
More...
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Target Organs:

      GSK-3 inhibitor TargetMol T2261

    • Bio Activity:

      GSK-3 MedChem Express HY-12292
      GSK-3?? TargetMol T2261
      IM-12 is a potent GSK-3? inhibitor with IC50 of 53 nM; shows a significant activity in several biological tests which was comparable or even outplayed the effects of the known SB-216763.; IC50 value: 53 nM [1]; Target: GSK-3? inhibitor; IM-12 acts as GSK-3b inhibitor resulting in the activation of downstream components of canonical Wnt signalling and has an adjacent positive impact on the neuronal differentiation in human neural progenitor cells [1]. MedChem Express HY-12292
      PI3K/Akt/mTOR MedChem Express HY-12292
      PI3K/Akt/mTOR Signaling TargetMol T2261
      PI3K/Akt/mTOR; MedChem Express HY-12292

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.3±0.1 g/cm3
Boiling Point: 600.2±55.0 °C at 760 mmHg
Vapour Pressure: 0.0±1.7 mmHg at 25°C
Enthalpy of Vaporization: 89.3±3.0 kJ/mol
Flash Point: 316.8±31.5 °C
Index of Refraction: 1.675
Molar Refractivity: 105.3±0.4 cm3
#H bond acceptors: 5
#H bond donors: 2
#Freely Rotating Bonds: 5
#Rule of 5 Violations: 0
ACD/LogP: 4.02
ACD/LogD (pH 5.5): 3.42
ACD/BCF (pH 5.5): 234.62
ACD/KOC (pH 5.5): 1731.03
ACD/LogD (pH 7.4): 3.42
ACD/BCF (pH 7.4): 234.63
ACD/KOC (pH 7.4): 1731.11
Polar Surface Area: 65 Å2
Polarizability: 41.7±0.5 10-24cm3
Surface Tension: 61.8±5.0 dyne/cm
Molar Volume: 280.2±5.0 cm3

Click to predict properties on the Chemicalize site


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