Found 6007 results

Search term: MF = 'C_{21}H_{21}N_{3}O_{2}S'
ChemSpider 2D Image | AZD 1208 | C21H21N3O2S

AZD 1208

  • Molecular FormulaC21H21N3O2S
  • Average mass379.475 Da
  • Monoisotopic mass379.135437 Da
  • ChemSpider ID28510573

  • Double-bond stereo - Double-bond stereo

    defined stereocentres - 1 of 1 defined stereocentres

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(5Z)-5-({2-[(3R)-3-Amino-1-piperidinyl]-3-biphenylyl}methylen)-1,3-thiazolidin-2,4-dion [German] [ACD/IUPAC Name]
(5Z)-5-({2-[(3R)-3-Amino-1-piperidinyl]-3-biphenylyl}methylene)-1,3-thiazolidine-2,4-dione [ACD/IUPAC Name]
(5Z)-5-({2-[(3R)-3-Amino-1-pipéridinyl]-3-biphénylyl}méthylène)-1,3-thiazolidine-2,4-dione [French] [ACD/IUPAC Name]
1204144-28-4 [RN]
2,4-Thiazolidinedione, 5-[[2-[(3R)-3-amino-1-piperidinyl][1,1'-biphenyl]-3-yl]methylene]-, (5Z)- [ACD/Index Name]
AZD 1208
AZD-1208
S98NFM1378
(5Z)-[[2-[(3R)-3-amino-1-piperidinyl][1,1'-biphenyl]-3-yl]methylene]-2,4-thiazolidinedione
(5Z)-5-[[2-[(3R)-3-Amino-1-piperidinyl][1,1'-biphenyl]-3-yl]methylene]-2,4-thiazolidinedione
More...
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      AZD1208 is a novel, orally bioavailable, highly selective PIM kinases inhibitor with single nanomolar potency against all three PIM kinases and is currently undergoing Phase I testing and dose escalation studies in AML.; IC50 Value: < 5 nM; Target: pan-Pim kinase; AZD1208 suppresses the growth of MOLM 16 and KG 1 xenograft tumors in vivo in a dosedependent manner. MedChem Express HY-15604
      AZD1208 is a novel, orally bioavailable, highly selective PIM kinases inhibitor with single nanomolar potency against all three PIM kinases and is currently undergoing Phase I testing and dose escalation studies in AML.;IC50 Value: < 5 nM;Target: pan-Pim kinaseAZD1208 suppresses the growth of MOLM 16 and KG 1 xenograft tumors in vivo in a dosedependent manner. Furthermore, AZD1208 leads to potent inhibition of colony development of primary AML cells from bone marrow aspirates and downregulates the phosphorylation of PIM goals. AZD1208 inhibits the growth of several AML cell lines and sensitivity correlates with the level of PIM1 expression, STAT5 activation and presence of protein tyrosine kinase mutation. AZD1208 causes cell cycle arrest and apoptosis in MOLM-16 cells in culture. MedChem Express HY-15604
      Enzymes Tocris Bioscience 6310
      JAK/STAT Signaling MedChem Express HY-15604
      JAK/STAT Signaling; MedChem Express HY-15604
      Kinases Tocris Bioscience 6310
      Pim MedChem Express HY-15604
      Pim Kinase Tocris Bioscience 6310
      Potent pan Pim kinase inhibitor Tocris Bioscience 6310
      Potent pan Pim kinase inhibitor (IC50 values are 0.4, 1.9 and 5.0 nM for Pim-1, 3 and 2, respectively). Exhibits >43-fold higher affinity for Pim kinases over a range of other kinases. Induces cell cycle arrest and apoptosis in AML cell lines in vitro and inhibits growth of tumor xenografts in vivo. Chemosensitizer. Tocris Bioscience 6310

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.3±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.677
Molar Refractivity: 109.2±0.3 cm3
#H bond acceptors: 5
#H bond donors: 3
#Freely Rotating Bonds: 3
#Rule of 5 Violations: 0
ACD/LogP: 2.38
ACD/LogD (pH 5.5): -0.75
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 1.00
ACD/LogD (pH 7.4): -0.18
ACD/BCF (pH 7.4): 1.00
ACD/KOC (pH 7.4): 1.36
Polar Surface Area: 101 Å2
Polarizability: 43.3±0.5 10-24cm3
Surface Tension: 59.1±3.0 dyne/cm
Molar Volume: 290.1±3.0 cm3

Click to predict properties on the Chemicalize site


Advertisement