Found 6 results

Search term: YTRRAUACYORZLX (Found by InChIKey (skeleton match))
ChemSpider 2D Image | NLG919 | C18H22N2O

NLG919

  • Molecular FormulaC18H22N2O
  • Average mass282.380 Da
  • Monoisotopic mass282.173218 Da
  • ChemSpider ID29315070

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1402836-58-1 [RN]
1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethan-1-ol
1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol [German] [ACD/IUPAC Name]
1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol [ACD/IUPAC Name]
1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)éthanol [French] [ACD/IUPAC Name]
1-cyclohexyl-2-{5H-imidazo[4,3-a]isoindol-5-yl}ethan-1-ol
1-cyclohexyl-2-{5H-imidazo[4,3-a]isoindol-5-yl}ethanol
5H-Imidazo[5,1-a]isoindole-5-ethanol, α-cyclohexyl- [ACD/Index Name]
NLG919
(±)-NLG-919
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

NLG-919 [DBID]
CCRIS 4693 [DBID]
GDC-0919 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Target Organs:

      IDO inhibitor TargetMol T1806

    • Bio Activity:

      IDO MedChem Express HY-13983
      IDO TargetMol T1806
      Metabolic Enzyme/Protease; MedChem Express HY-13983
      Metabolism TargetMol T1806
      NLG919 is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with Ki/EC50 of 7 nM/75 nM. MedChem Express
      NLG919 is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with Ki/EC50 of 7 nM/75 nM.; IC50 value: 7 nM/75 nM(Ki/EC50); Target: indoleamine-(2,3)-dioxygenase inhibitor; NLG919 potently blocks IDO-induced T-cell suppression and restored robust T-cell responses with ED50 of 80 nM. MedChem Express HY-13983
      NLG919 is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with Ki/EC50 of 7 nM/75 nM.;IC50 value: 7 nM/75 nM(Ki/EC50);Target: indoleamine-(2,3)-dioxygenase inhibitorNLG919 potently blocks IDO-induced T-cell suppression and restored robust T-cell responses with ED50 of 80 nM. Similarly, using IDO-expressing mouse DCs from tumor-draining lymph nodes, NLG919 abrogated IDO-induced suppression of antigen-specific T cells (OT-I) in vitro, with ED50 of 120 nM. In mice, a single oral administration of NLG919 reduces the concentration of plasma and tissue Kyn by ~ 50%. In mice bearing B16F10 tumors, NLG919 markedly enhances the antitumor responses of naive, resting pmel-1 cells to vaccination with cognate hgp100 peptide plus CpG-1826 in IFA. MedChem Express HY-13983
      Others MedChem Express HY-13983

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.3±0.1 g/cm3
Boiling Point: 524.6±33.0 °C at 760 mmHg
Vapour Pressure: 0.0±1.4 mmHg at 25°C
Enthalpy of Vaporization: 84.1±3.0 kJ/mol
Flash Point: 271.1±25.4 °C
Index of Refraction: 1.676
Molar Refractivity: 83.2±0.5 cm3
#H bond acceptors: 3
#H bond donors: 1
#Freely Rotating Bonds: 3
#Rule of 5 Violations: 0
ACD/LogP: 3.28
ACD/LogD (pH 5.5): 2.61
ACD/BCF (pH 5.5): 35.19
ACD/KOC (pH 5.5): 251.83
ACD/LogD (pH 7.4): 3.45
ACD/BCF (pH 7.4): 241.29
ACD/KOC (pH 7.4): 1726.81
Polar Surface Area: 38 Å2
Polarizability: 33.0±0.5 10-24cm3
Surface Tension: 50.6±7.0 dyne/cm
Molar Volume: 221.1±7.0 cm3

Click to predict properties on the Chemicalize site


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