ChemSpider 2D Image | XL413 (hydrochloride) | C14H13Cl2N3O2

XL413 (hydrochloride)

  • Molecular FormulaC14H13Cl2N3O2
  • Average mass326.178 Da
  • Monoisotopic mass325.038483 Da
  • ChemSpider ID30689922

  • defined stereocentres - 1 of 1 defined stereocentres

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1169562-71-3 [RN]
2062200-97-7 [RN]
8-Chlor-2-[(2S)-2-pyrrolidinyl][1]benzofuro[3,2-d]pyrimidin-4(1H)-onhydrochlorid (1:1) [German] [ACD/IUPAC Name]
8-Chloro-2-[(2S)-2-pyrrolidinyl][1]benzofuro[3,2-d]pyrimidin-4(1H)-one hydrochloride (1:1) [ACD/IUPAC Name]
8-Chloro-2-[(2S)-2-pyrrolidinyl][1]benzofuro[3,2-d]pyrimidin-4(1H)-one, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
Benzofuro[3,2-d]pyrimidin-4(3H)-one, 8-chloro-2-[(2S)-2-pyrrolidinyl]-, hydrochloride (1:1) [ACD/Index Name]
BMS-863233 HYDROCHLORIDE
XL413 (hydrochloride)
(S)-8-chloro-2-(pyrrolidin-2-yl)benzofuro[3,2-d]pyrimidin-4(3H)-one hydrochloride
[1169562-71-3] [RN]
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

JG305JRH1Z [DBID]
BMS 863233 | [DBID]
CCRIS 4693 [DBID]
PubChem Substance ID 329825761 [DBID]
UNII:JG305JRH1Z [DBID]
UNII-JG305JRH1Z [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      Cdc7 MedChem Express HY-15260A
      Cell Cycle/DNA Damage MedChem Express HY-15260A
      Cell Cycle/DNA Damage; MedChem Express HY-15260A
      Enzymes Tocris Bioscience 5493
      Kinases Tocris Bioscience 5493
      Other Kinases Tocris Bioscience 5493
      Potent and selective Cdc7 inhibitor Tocris Bioscience 5493
      Potent and selective Cdc7 inhibitor (IC50 = 3.4 nM). Exhibits >12-fold selectivity for Cdc7 over PIM-1 kinase and >30-fold selectivity over pMCM and CK2. Inhibits proliferation of Colo 205 cells in vi tro and attenuates tumor growth of Colo 205 xenografts in mice. Tocris Bioscience 5493
      Potent and selective Cdc7 inhibitor (IC50 = 3.4 nM). Exhibits >12-fold selectivity for Cdc7 over PIM-1 kinase and >30-fold selectivity over pMCM and CK2. Inhibits proliferation of Colo 205 cells in vitro and attenuates tumor growth of Colo 205 xenografts in mice. Tocris Bioscience 5493
      XL413 is a potent and selective Cdc7 inhibitor with an IC50 of 3.7 nM, MedChem Express http://www.medchemexpress.com/zosuquidar.html
      XL413 is a potent and selective Cdc7 inhibitor with an IC50 of 3.7 nM, >60-fold selectivity against CK2, >10-fold selectivity against PIM, and >300-fold selectivity against a panel of over 100 protein kinases. MedChem Express HY-15260A
      XL413 is a potent and selective Cdc7 inhibitor with an IC50 of 3.7 nM, >60-fold selectivity against CK2, >10-fold selectivity against PIM, and >300-fold selectivity against a panel of over 100 protein kinases. Phase 1;IC50 value: 3.7 nM [1];Target: Selective Cdc 7XL413 demonstrated excellent plasma exposures in mice [100 mg/kg (PO): 141 lM (1 h), 81 lM (4 h)]. Prolonged treatment with XL413 (3 days) inhibited the cell proliferation (IC50 = 2685 nM), decreased cell viability (IC50 = 2142 nM) and elicited the caspase 3/7 activity (EC50 = 2288 nM) in Colo-205 cells.XL413 demonstrated an excellent exposure profile infull rat PK assay (dosed at 3 mg/kg: Cmax (PO) = 8.61 lM, AUC(po) = 75 lM h, CL = 117 mL/h kg, Vss = 0.55 L/kg, T1/2 = 2.32 h, F = 95%). Tumor bearing mice were administered XL413 orally at doses of 10, 30, or 100 mg/kg once daily (qd) for 14 days,XL413 was well tolerated at all the doses and regimens examined, with no significant body weight loss observed [1]. MedChem Express HY-15260A

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

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