ChemSpider 2D Image | Agomelatine hydrochloride | C15H18ClNO2

Agomelatine hydrochloride

  • Molecular FormulaC15H18ClNO2
  • Average mass279.762 Da
  • Monoisotopic mass279.102600 Da
  • ChemSpider ID35308334

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1176316-99-6 [RN]
Acetamide, N-[2-(7-methoxy-1-naphthalenyl)ethyl]-, hydrochloride (1:1) [ACD/Index Name]
Agomelatine hydrochloride
N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide hydrochloride (1:1) [ACD/IUPAC Name]
N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamidhydrochlorid (1:1) [German] [ACD/IUPAC Name]
N-[2-(7-Méthoxy-1-naphtyl)éthyl]acétamide, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
N-[2-(7-METHOXYNAPHTHALEN-1-YL)ETHYL]ACETAMIDE HYDROCHLORIDE
Agomelatine (hydrochloride)
Hydrochloride
N-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide
More...
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      5-HT Receptor MedChem Express HY-17038A
      Agomelatine hydrochloride is a antidepressant, which is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor. MedChem Express , HY-17038A
      Agomelatine hydrochloride is a antidepressant, which is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor. ;IC50 value: 6.2 (pKi, 5-HT2c); 6.6 (pKi, 5-HT2b);Target: 5-HT 2c receptor Agomelatine hydrochloride is an antidepressant drug. It is classified as a norepinephrine-dopamine disinhibitor (NDDI) due to its antagonism of the 5-HT2C receptor. Activation of 5-HT2C receptors by serotonin inhibits dopamine and norepinephrine release. Antagonism of 5-HT2C results in an enhancement of DA and NE release and activity of frontocortical dopaminergic and adrenergic pathways [1]. A total of 42 rats were divided into 7 groups as each composed of 6 rats: (1) intact, (2) 40 mg/kg agomelatine, (3) 140 mg/kg N-acetylcysteine (NAC), (4) 2 g/kg paracetamol, (5) 2 g/kg paracetamol + 140 mg/kg NAC, (6) 2 g/kg paracetamol + 20 mg/kgagomelatine, and (7) 2 g/kg paracetamol + 40 mg/kg agomelatine groups. Paracetamol-induced hepatotoxicity was ap MedChem Express HY-17038A
      GPCR/G protein MedChem Express HY-17038A
      GPCR/G protein; Nueronal Signaling; MedChem Express HY-17038A

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

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