Tozasertib

234335M86K

639089-54-6

Cyclopropanecarboxamide, N-[4-[[4-(4-methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]-

N-[4-({4-(4-Methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl}sulfanyl)phenyl]cyclopropancarboxamid

N-[4-({4-(4-Methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl}sulfanyl)phenyl]cyclopropanecarboxamide

N-[4-({4-(4-Méthyl-1-pipérazinyl)-6-[(5-méthyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl}sulfanyl)phényl]cyclopropanecarboxamide

N-[4-({4-(4-Methylpiperazin-1-yl)-6-[(3-methyl-1H-pyrazol-5-yl)amino]pyrimidin-2-yl}sulfanyl)phenyl]cyclopropanecarboxamide

N-[4-({4-[(5-methyl-1H-pyrazol-3-yl)amino]-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl}sulfanyl)phenyl]cyclopropanecarboxamide

Tozasertib

tozasertib

tozasertib

tozasertibum

1010423-95-6

13551-92-3

99%

AAK1_HUMAN

AAPK1_HUMAN

AAPK2_HUMAN

ABL1_HUMAN

ABL2_HUMAN

ACK1_HUMAN

Activated CDC42 kinase 1

Activin receptor type-1

ACVR1_HUMAN

ALK tyrosine kinase receptor

ALK_HUMAN

Angiopoietin-1 receptor

ANKK1_HUMAN

AP2-associated protein kinase 1

Aromatase

AURKA_HUMAN

AURKA_MOUSE

AURKB_HUMAN

AURKC_HUMAN

Aurora kinase A

Aurora kinase B

Aurora kinase C

BDNF/NT-3 growth factors receptor

BLK_HUMAN

BMP-2-inducible protein kinase

BMP2K_HUMAN

BMPR2_HUMAN

BMX_HUMAN

BTK_HUMAN

Casein kinase II subunit alpha

Casein kinase II subunit α′

CD11A_HUMAN

CD11B_HUMAN

CDK16_HUMAN

CDK1_HUMAN

CDK2_HUMAN

CP19A_HUMAN

CSF1R_HUMAN

CSK21_HUMAN

CSK22_HUMAN

CSK_HUMAN

Cyclin-dependent kinase 1

Cyclin-dependent kinase 11A

Cyclin-dependent kinase 11B

Cyclin-dependent kinase 16

Cyclin-dependent kinase 2

Cyclin-G-associated kinase

Cyclopropane carboxylic acid{4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)-pyrimidin-2-ylsulphanyl]-phenyl}-amide

Cyclopropanecarboxamide,N-[4-[[4-(4-methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]-

Cyclopropanecarboxylic Acid {4-[4-(4-Methyl-Piperazin -1-Yl)-6-(5-Methyl-2h-Pyrazol-3-Ylamino)-Pyrimidin-2-Ylsulfanyl]-Phenyl}-Amide

Cyclopropanecarboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-1H-pyrazol-3-ylamino)-pyrimidin-2; -ylsulfanyl]-phenyl}-amide

Cyclopropanecarboxylic Acid {4-[4-(4-Methyl-Piperazin-1-Yl)-6-(5-Methyl-2h-Pyrazol-3-Ylamino)-Pyrimidin-2-Ylsulfanyl]-Phenyl}-Amide

cyclopropyl-N-(4-{6-(4-methylpiperazinyl)-4-[(5-methylpyrazol-3-yl)amino]pyrimidin-2-ylthio}phenyl)carboxamide

Cytoplasmic tyrosine-protein kinase BMX

DCLK3_HUMAN

DDR1_HUMAN

DDR2_HUMAN

Desmethylmisonidazole

Discoidin domain-containing receptor 2

E2AK4_HUMAN

eIF-2-α kinase GCN2

EPHA1_HUMAN

EPHA2_HUMAN

EPHA3_HUMAN

EPHA4_HUMAN

EPHA8_HUMAN

EPHB1_HUMAN

EPHB4_HUMAN

Ephrin type-A receptor 1

Ephrin type-A receptor 2

Ephrin type-A receptor 3

Ephrin type-A receptor 3 [1-975]

Ephrin type-A receptor 4

Ephrin type-A receptor 8

Ephrin type-B receptor 1

Ephrin type-B receptor 4

FAK2_HUMAN

FGFR1_HUMAN

FGFR2_HUMAN

FGFR3_HUMAN

FGFR4_HUMAN

FGR_HUMAN

Fibroblast growth factor receptor 1

Fibroblast growth factor receptor 2

Fibroblast growth factor receptor 3

Fibroblast growth factor receptor 4

FLT3_HUMAN

FRK_HUMAN

FYN_HUMAN

GAK_HUMAN

Hepatocyte growth factor receptor

IKKE_HUMAN

INSR_HUMAN

Insulin receptor

IRAK3_HUMAN

ITK_HUMAN

JAK2_HUMAN

JAK3_HUMAN

KCC1D_HUMAN

KIT_HUMAN

KS6A2_HUMAN

KS6A3_HUMAN

KSYK_HUMAN

LATS1_HUMAN

LCK_HUMAN

LIM domain kinase 1

LIMK1_HUMAN

LYN_HUMAN

M3K10_HUMAN

M3K11_HUMAN

M3K12_HUMAN

M3K20_HUMAN

M3K4_HUMAN

M3K9_HUMAN

M4K1_HUMAN

M4K3_HUMAN

M4K4_HUMAN

M4K5_HUMAN

MARK1_HUMAN

MARK2_HUMAN

MARK3_HUMAN

MARK4_HUMAN

MELK_HUMAN

MERTK_HUMAN

MET_HUMAN

MFCD10565966

MFCD13185152

Mitogen-activated protein kinase 10

MK-0457;VX-680;MK0457;VX680;VX 680;MK 0457

MK10_HUMAN

MP2K1_HUMAN

MP2K2_HUMAN

MP2K6_HUMAN

MUSK_HUMAN

MYLK2_HUMAN

MYLK3_HUMAN

MYLK4_HUMAN

Myosin light chain kinase 3

N-(4-((4-((3-methyl-1H-pyrazol-5-yl)amino)-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl)thio)phenyl)cyclopropanecarboxamide

N-(4-((4-((5-methyl-1H-pyrazol-3-yl)amino)-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl)thio)phenyl)cyclopropanecarboxamide

N-(4-(4-(3-methyl-1H-pyrazol-5-ylamino)-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylthio)phenyl)cyclopropanecarboxamide

N-[4-({4-[(3-methyl-1H-pyrazol-5-yl)amino]-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl}sulfanyl)phenyl]cyclopropanecarboxamide

N-[4-({4-[(5-METHYL-2H-PYRAZOL-3-YL)AMINO]-6-(4-METHYLPIPERAZIN-1-YL)PYRIMIDIN-2-YL}SULFANYL)PHENYL]CYCLOPROPANECARBOXAMIDE

N-[4-[4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]sulfanylphenyl]cyclopropanecarboxamide

N-[4-[[4-(4-methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]-Cyclopropanecarboxamide

N-[4-[[4-(4-Methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]cyclopropanecarboxamide

N-[4-[[4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]thio]phenyl]cyclopropanecarboxamide

NEK5_HUMAN

NT-3 growth factor receptor

NTRK1_HUMAN

NTRK2_HUMAN

NTRK3_HUMAN

NUAK family SNF1-like kinase 1

NUAK family SNF1-like kinase 2

NUAK1_HUMAN

NUAK2_HUMAN

P2Y purinoceptor 14

P2Y14_HUMAN

PAK1_HUMAN

PAK2_HUMAN

PAK3_HUMAN

PAK4_HUMAN

PAK5_HUMAN

PGFRA_HUMAN

PGFRB_HUMAN

PHKG1_HUMAN

PI42B_HUMAN

PI51A_HUMAN

PKN1_HUMAN

PLK1_HUMAN

PLK2_HUMAN

PLK3_HUMAN

PLK4_HUMAN

Protein-tyrosine kinase 2-β

RET_HUMAN

Ribosomal protein S6 kinase α-2

Ribosomal protein S6 kinase α-3

RIOK1_HUMAN

RIOK3_HUMAN

RIPK1_HUMAN

ROS1_HUMAN

Serine/threonine-protein kinase 16

Serine/threonine-protein kinase 24

Serine/threonine-protein kinase 25

Serine/threonine-protein kinase 3

Serine/threonine-protein kinase 4

Serine/threonine-protein kinase DCLK3

Serine/threonine-protein kinase LATS1

Serine/threonine-protein kinase MARK1

Serine/threonine-protein kinase MARK2

Serine/threonine-protein kinase N1

Serine/threonine-protein kinase Nek5

Serine/threonine-protein kinase PAK 1

Serine/threonine-protein kinase PAK 2

Serine/threonine-protein kinase PAK 3

Serine/threonine-protein kinase PAK 4

Serine/threonine-protein kinase PAK 5

Serine/threonine-protein kinase PLK1

Serine/threonine-protein kinase PLK2

Serine/threonine-protein kinase PLK3

Serine/threonine-protein kinase PLK4

Serine/threonine-protein kinase RIO1

Serine/threonine-protein kinase RIO3

Serine/threonine-protein kinase SIK1

Serine/threonine-protein kinase SIK2

Serine/threonine-protein kinase STK11

SIK1_HUMAN

SIK2_HUMAN

SLK_HUMAN

SRC_HUMAN

SRPK1_HUMAN

SRPK2_HUMAN

SRSF protein kinase 1

SRSF protein kinase 2

STK11_HUMAN

STK16_HUMAN

STK24_HUMAN

STK25_HUMAN

STK3_HUMAN

STK4_HUMAN

TESK1_HUMAN

TIE1_HUMAN

TIE2_HUMAN

TNIK_HUMAN

TNK1_HUMAN

Tozasertib (VX-680)

tozasertib (vx-680, mk-0457)

Tozasertib (VX-680, MK-0457, VX6)

Tozasertib(MK-0457,VX-680)

tozasertib(vx-680)

tozasertibum

tozasertib，vx-680/mk-0457

tozasertib；vx680；mk0457

TXK_HUMAN

Tyrosine-protein kinase ABL1

Tyrosine-protein kinase ABL1 [201-500]

Tyrosine-protein kinase ABL1 [T315I]

Tyrosine-protein kinase ABL2

Tyrosine-protein kinase Blk

Tyrosine-protein kinase BTK

Tyrosine-protein kinase CSK

Tyrosine-protein kinase Fgr

Tyrosine-protein kinase FRK

Tyrosine-protein kinase Fyn

Tyrosine-protein kinase ITK/TSK

Tyrosine-protein kinase JAK2

Tyrosine-protein kinase JAK3

Tyrosine-protein kinase Lck

Tyrosine-protein kinase Lyn

Tyrosine-protein kinase Mer

Tyrosine-protein kinase receptor Tie-1

Tyrosine-protein kinase receptor UFO

Tyrosine-protein kinase SYK

Tyrosine-protein kinase TXK

Tyrosine-protein kinase Yes

UFO_HUMAN

VGFR1_HUMAN

VGFR2_HUMAN

VGFR3_HUMAN

VX-680 (MK-0457,Tozasertib)

VX-680 (Tozasertib, MK-0457)

vx-680, mk-0457, tozasertib

Wee1-like protein kinase

WEE1_HUMAN

YES_HUMAN

тозасертиб

توزاسارتيب

托泽色替