Found 19 results

Search term: MF = 'C_{32}H_{28}F_{3}N_{5}O_{4}'
ChemSpider 2D Image | AMG-487 | C32H28F3N5O4

AMG-487

  • Molecular FormulaC32H28F3N5O4
  • Average mass603.591 Da
  • Monoisotopic mass603.209351 Da
  • ChemSpider ID8457740

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

AMG-487
Benzeneacetamide, N-[1-[3-(4-ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-N-(3-pyridinylmethyl)-4-(trifluoromethoxy)- [ACD/Index Name]
N-{1-[3-(4-Ethoxyphenyl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl]ethyl}-N-(3-pyridinylmethyl)-2-[4-(trifluormethoxy)phenyl]acetamid [German] [ACD/IUPAC Name]
N-{1-[3-(4-Ethoxyphenyl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl]ethyl}-N-(3-pyridinylmethyl)-2-[4-(trifluoromethoxy)phenyl]acetamide [ACD/IUPAC Name]
N-{1-[3-(4-Éthoxyphényl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl]éthyl}-N-(3-pyridinylméthyl)-2-[4-(trifluorométhoxy)phényl]acétamide [French] [ACD/IUPAC Name]
(��)-AMG 487
(?)-AMG 487
(±)-AMG 487
(±)-AMG 487
[947536-03-0] [RN]
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

CCRIS 4693 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      7-TM Receptors Tocris Bioscience 4487
      Antagonist of CXCR3; inhibits binding of 125I-IP-10 and 125I-ITAC to CXCR3 (IC50 values are 8.0 and 8.2 nM respectively). Inhibits CXCR3-mediated cell migration by the chemokines IP-10, ITAC and MiG i n vitro (IC50 values are 8, 15 and 36 nM respectively). Also shown to inhibit lung metastasis in a mouse model of metastatic breast cancer. Tocris Bioscience 4487
      Antagonist of CXCR3; inhibits binding of 125I-IP-10 and 125I-ITAC to CXCR3 (IC50 values are 8.0 and 8.2 nM respectively). Inhibits CXCR3-mediated cell migration by the chemokines IP-10, ITAC and MiG in vitro (IC50 values are 8, 15 and 36 nM respectively). Also shown to inhibit lung metastasis in a mouse model of metastatic breast cancer. Tocris Bioscience 4487
      Antagonist of CXCR3; inhibits binding of 125I-IP-10 and 125I-ITAC to CXCR3 (IC50 values are 8.0 and 8.2 nM respectively). Inhibits CXCR3-mediated cell migration by the chemokines IP-10, ITAC and MiG in vitro (IC50 values are 8, 15 and 36 nM respectively). Also shown to inhibit lung metastasis in a mouse model of metastatic breast cancer. This product is racemic. Tocris Bioscience 4487
      Chemokine CXC Receptors Tocris Bioscience 4487
      Chemokine Receptors Tocris Bioscience 4487
      CXCR3 antagonist; inhibits cell migration and metastasis Tocris Bioscience 4487

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.3±0.1 g/cm3
Boiling Point: 750.0±70.0 °C at 760 mmHg
Vapour Pressure: 0.0±2.5 mmHg at 25°C
Enthalpy of Vaporization: 109.3±3.0 kJ/mol
Flash Point: 407.4±35.7 °C
Index of Refraction: 1.606
Molar Refractivity: 158.6±0.5 cm3
#H bond acceptors: 9
#H bond donors: 0
#Freely Rotating Bonds: 11
#Rule of 5 Violations: 1
ACD/LogP: 3.76
ACD/LogD (pH 5.5): 3.65
ACD/BCF (pH 5.5): 347.01
ACD/KOC (pH 5.5): 2251.66
ACD/LogD (pH 7.4): 3.68
ACD/BCF (pH 7.4): 368.39
ACD/KOC (pH 7.4): 2390.40
Polar Surface Area: 97 Å2
Polarizability: 62.9±0.5 10-24cm3
Surface Tension: 45.5±7.0 dyne/cm
Molar Volume: 459.7±7.0 cm3

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