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Search term: 29315067 (Found by CSID)
ChemSpider 2D Image | AZD3463 | C24H25ClN6O

AZD3463

  • Molecular FormulaC24H25ClN6O
  • Average mass448.948 Da
  • Monoisotopic mass448.177826 Da
  • ChemSpider ID29315067

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1356962-20-3 [RN]
2-Pyrimidinamine, N-[4-(4-amino-1-piperidinyl)-2-methoxyphenyl]-5-chloro-4-(1H-indol-3-yl)- [ACD/Index Name]
AZD 3463
AZD3463
N-[4-(4-Amino-1-piperidinyl)-2-methoxyphenyl]-5-chlor-4-(1H-indol-3-yl)-2-pyrimidinamin [German] [ACD/IUPAC Name]
N-[4-(4-Amino-1-piperidinyl)-2-methoxyphenyl]-5-chloro-4-(1H-indol-3-yl)-2-pyrimidinamine [ACD/IUPAC Name]
N-[4-(4-Amino-1-pipéridinyl)-2-méthoxyphényl]-5-chloro-4-(1H-indol-3-yl)-2-pyrimidinamine [French] [ACD/IUPAC Name]
N-[4-(4-aminopiperidin-1-yl)-2-methoxyphenyl]-5-chloro-4-(1H-indol-3-yl)pyrimidin-2-amine
[1356962-20-3] [RN]
1-(5-nitroindolin-1-yl)ethanone
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

PubChem Substance ID 329825761 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Target Organs:

      TGF-beta/Smad inhibitor TargetMol T1967

    • Chemical Class:

      A member of the class of indoles that is 1H-indole substituted by a 2-[4-(4-aminopiperidin-1-yl)-2-methoxyanilino]-5-chloropyrimidin-4-yl group at position 3. It is an orally bioavailable dual inhibit or of ALK and IGF1R with Ki value of 0.75 nM for ALK. ChEBI CHEBI:167653

    • Bio Activity:

      ALK MedChem Express HY-15609
      ALK TargetMol T1967
      ALK IGF-1R MedChem Express HY-15609
      AZD-3463 is an ALK/IGF1R inhibitor which overcomes multiple mechanisms of acquired resistance to crizotinib.; IC50 Value:; Target: ALK/IGF1R; MedChem Express HY-15609
      AZD-3463 is an ALK/IGF1R inhibitor which overcomes multiple mechanisms of acquired resistance to crizotinib.;IC50 Value:;Target: ALK/IGF1R MedChem Express HY-15609
      Protein Tyrosine Kinase/RTK MedChem Express HY-15609
      Protein Tyrosine Kinase/RTK; MedChem Express HY-15609
      Tyrosine Kinase/Adaptors TargetMol T1967

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.3±0.1 g/cm3
Boiling Point: 723.6±70.0 °C at 760 mmHg
Vapour Pressure: 0.0±2.3 mmHg at 25°C
Enthalpy of Vaporization: 105.7±3.0 kJ/mol
Flash Point: 391.4±35.7 °C
Index of Refraction: 1.693
Molar Refractivity: 128.6±0.3 cm3
#H bond acceptors: 7
#H bond donors: 4
#Freely Rotating Bonds: 5
#Rule of 5 Violations: 0
ACD/LogP: 3.11
ACD/LogD (pH 5.5): 0.91
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 2.92
ACD/LogD (pH 7.4): 1.70
ACD/BCF (pH 7.4): 3.24
ACD/KOC (pH 7.4): 17.93
Polar Surface Area: 92 Å2
Polarizability: 51.0±0.5 10-24cm3
Surface Tension: 65.4±3.0 dyne/cm
Molar Volume: 335.4±3.0 cm3

Click to predict properties on the Chemicalize site


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