ChemSpider 2D Image | MFCD00012407 | C31H30N2O7S2

MFCD00012407

  • Molecular FormulaC31H30N2O7S2
  • Average mass606.709 Da
  • Monoisotopic mass606.149414 Da
  • ChemSpider ID108971

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

16-(4-sulfo-2-sulfonatophenyl)-3-oxa-9??,23-diazaheptacyclo[17.7.1.1?,?.0²,¹?.0?,¹?.0²³,²?.0¹³,²?]octacosa-1(27),2(17),4,9(28),13,15,18-heptaen-9-ylium
1H,5H,11H,15H-Xantheno[2,3,4-ij:5,6,7-i'j']diquinolizinium, 9-(2,4-disulfophenyl)-2,3,6,7,12,13,16,17-octahydro-, inner salt [ACD/Index Name]
4-(2,3,6,7,12,13,16,17-Octahydro-1H,5H,11H,15H-pyrido[3,2,1-ij]chinolizino[1',9':6,7,8]chromeno[2,3-f]chinolin-18-ium-9-yl)-3-sulfobenzolsulfonat [German] [ACD/IUPAC Name]
4-(2,3,6,7,12,13,16,17-Octahydro-1H,5H,11H,15H-pyrido[3,2,1-ij]quinolizino[1',9':6,7,8]chroméno[2,3-f]quinoléin-18-ium-9-yl)-3-sulfobenzènesulfonate [French] [ACD/IUPAC Name]
4-(2,3,6,7,12,13,16,17-Octahydro-1H,5H,11H,15H-pyrido[3,2,1-ij]quinolizino[1',9':6,7,8]chromeno[2,3-f]quinolin-18-ium-9-yl)-3-sulfobenzenesulfonate [ACD/IUPAC Name]
MFCD00012407
Sulforhodamine 101
[60311-02-6] [RN]
116777-18-5 [RN]
123333-78-8 [RN]
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

3582548 [DBID]
FX0ES3271V [DBID]
284912_SIAL [DBID]
86184_FLUKA [DBID]
CCRIS 4693 [DBID]
S7635_SIGMA [DBID]
SR 101 [DBID]
UNII-FX0ES3271V [DBID]
  • References
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      <p><strong><span style=text-decoration: underline;>Overview</span></strong></p> <p>Sulforhodamine 101 (SR101) is a red fluorescent dye which is water-soluble and non-fixable.</p> <p>It is a preferential astrocyte marker both in vitro and in vivo and is frequently used in neurophysiological experiments. It also labels oligodendrocytes.</p> <p style=margin-bottom: 2em;>The exact uptake mechanism of SR101 is unclear. It is thought that SR-101 is taken up by astrocytes and diffuses through the astrocyte syncytium via gap junctions.</p> <p></p> <p><strong><span style=text-decoration: underline;>Uses and applications</span></strong></p> <p>The dye is commonly used for in vivo brain imaging and allows in vivo imaging of oligodendrocytes. It may be applied topically to the exposed cortex or administered via injection.</p> <p style=margin-bottom: 2em;>The dye has a wide range of applications. For example, it is often used to identify astrocytes, to counterstain astrocytes and has been extensively used with calcium-sensitive dyes to distinguish calcium signals derived from neurons and astrocytes.</p> <p><strong><span style=text-decoration: underline;>Caution and care</span></strong></p> <p>Care should be taken when using the dye is not as specific for astrocytes as initially reported and as the dye labels oligodendrocytes, it cannot be assumed that all SR101 labelled cells are astrocytes.</p> <p style=margin-bottom: 2em;>The dye also differs in staining intensity depending on the brain region being investigated (it does not label astrocytes in brainstem slices as strongly or specifically as in the hippocampus or cortex).</p> <p>SR101 also has effects on excitatory neuronal activity and can induce cortical seizure-like activity.</p> <p style=margin-bottom: 2em;>H&uuml;lsmann et al (2017) recommend that to minimize excitatory side effects, SR101 concentrations should be kept as low as possible or the labelling procedure could be carried out after the experiment.</p> <p style=margin-bottom: 2em;>If possible, researchers should carry out additional measures to confirm specificity of SR101 staining in their experiments (e.g. electrophysiological whole-cell recordings of SR101-labeled cells and post hoc IHC).</p> Hello Bio [HB0838]
      Fluorescent dye (excitation maximum ~ 586 nm; emission maximum ~ 606). Selective astrocyte marker. Sulforhodamine 101 acid chloride (Cat. No. 5442) also available. Tocris Bioscience 5146
      Fluorescent dye; selective astrocyte marker Tocris Bioscience 5146
      Fluorescent Dyes Tocris Bioscience 5146
      Fluorescent Dyes, Labels and Stains Tocris Bioscience 5146
      Fluorescent Imaging Tocris Bioscience 5146
      Imaging, dyes, stains & labels/Fluorescent probes Hello Bio [HB0838]
      Imaging, dyes, stains & labels/Labels, stains & dyes Hello Bio [HB0838]
      Reagents Tocris Bioscience 5146
      Red fluorescent dye. Preferential astrocyte marker. Also labels oligodendrocytes. Hello Bio [HB0838]

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density:
Boiling Point:
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Index of Refraction:
Molar Refractivity:
#H bond acceptors: 9
#H bond donors: 2
#Freely Rotating Bonds: 3
#Rule of 5 Violations:
ACD/LogP:
ACD/LogD (pH 5.5):
ACD/BCF (pH 5.5):
ACD/KOC (pH 5.5):
ACD/LogD (pH 7.4):
ACD/BCF (pH 7.4):
ACD/KOC (pH 7.4):
Polar Surface Area: 144 Å2
Polarizability:
Surface Tension:
Molar Volume:

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