ChemSpider 2D Image | 1-tert-Butyl-3-[2-{[4-(diethylamino)butyl]amino}-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea | C28H41N7O3

1-tert-Butyl-3-[2-{[4-(diethylamino)butyl]amino}-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea

  • Molecular FormulaC28H41N7O3
  • Average mass523.670 Da
  • Monoisotopic mass523.327087 Da
  • ChemSpider ID1358

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1-[2-{[4-(Diethylamino)butyl]amino}-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-(2-methyl-2-propanyl)harnstoff [German] [ACD/IUPAC Name]
1-[2-{[4-(Diethylamino)butyl]amino}-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-(2-methyl-2-propanyl)urea [ACD/IUPAC Name]
1-[2-{[4-(Diéthylamino)butyl]amino}-6-(3,5-diméthoxyphényl)pyrido[2,3-d]pyrimidin-7-yl]-3-(2-méthyl-2-propanyl)urée [French] [ACD/IUPAC Name]
1-tert-Butyl-3-[2-{[4-(diethylamino)butyl]amino}-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea
219580-11-7 [RN]
3-tert-butyl-1-(2-{[4-(diethylamino)butyl]amino}-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea
MFCD08705327 [MDL number]
N-[2-[[4-(Diethylamino)butyl]amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea
Urea, N-[2-[[4-(diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)- [ACD/Index Name]
[219580-11-7] [RN]
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

A4TLL8634Y [DBID]
PD 173074 [DBID]
PD-173074 [DBID]
NBI 34060 | [DBID]
NCGC00165863-01 [DBID]
P2499_SIGMA [DBID]
PD 173074,PD-173074 [DBID]
PD 173074;n-[2-[[4-(diethylamino)butyl]amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-n'-(1,1-dimethylethyl)urea [DBID]
PD 173074;PD-173074 [DBID]
PD 173074|PD-173074 [DBID]
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  • References
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Safety:

      Sold for research purposes under agreement from Pfizer Inc. Tocris Bioscience 3044

    • Target Organs:

      FGFR inhibitor; VEGFR inhibitor; Src inhibitor TargetMol T2642

    • Chemical Class:

      A member of the class of ureas that is 1-<ital>tert</ital>-butylurea in which one of the hydrogens attached to <element>N</element><smallsup>3</smallsup> is substituted by a pyrido[2,3-<ital>d</ital>] pyrimidin-7-yl group, which is itself substituted at positions 2 and 6 by a 4-(diethylamino)butyl]amino group and a 3,5-dimethoxyphenyl group, respectively. It is a FGF/VEGF receptor tyrosine kinase i nhibitor. ChEBI CHEBI:63448
      A member of the class of ureas that is 1-tert-butylurea in which one of the hydrogens attached to N(3) is substituted by a pyrido[2,3-d]pyrimidin-7-yl group, which is itself substituted at positions 2 and 6 by a 4-(diethylamino)butyl]amino group and a 3,5-dimethoxyphenyl group, respectively. It is a FGF/VEGF receptor tyrosine kinase inhibitor. ChEBI CHEBI:63448

    • Bio Activity:

      Biochemicals & small molecules/Antagonists & inhibitors Hello Bio HB3584
      Cell process/Stem cells/Differentiation Hello Bio HB3584
      Cell process/Stem cells/Proliferation Hello Bio HB3584
      Enzyme-Linked Receptors Tocris Bioscience 3044
      FGFR Tocris Bioscience 3044
      FGFR MedChem Express HY-10321
      FGFR1 and -3 inhibitor Tocris Bioscience 3044
      FGFR1/ FGFR3 inhibitor (IC<sub>50</sub> values are 22 and 5 nM respectively). Inhibits angiogenesis. Also inhibits oligodendrocyte progenitor proliferation and differentiation. Hello Bio HB3584
      FGFR1/ FGFR3 inhibitor. Inhibits oligodendrocyte progenitor proliferation and differentiation. Hello Bio HB3584
      FGFR1;VEGFR2;c-Src;EGFR TargetMol T2642
      PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM, ~1000-fold selective for FGFR1 than PDGFR and c-Src. MedChem Express
      PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM, ~1000-fold selective for FGFR1 than PDGFR and c-Src.; IC50 value: ~25 nM (FGFR1); 100-200 nM (VEGFR2) [1]; Target: FGFR1; VEGFR; in vitro: PD173074 is an ATP-competitive inhibitor of FGFR1 with Ki of ~40 nM. MedChem Express HY-10321
      PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM, ~1000-fold selective for FGFR1 than PDGFR and c-Src.;IC50 value: ~25 nM (FGFR1); 100-200 nM (VEGFR2) [1];Target: FGFR1; VEGFR;In vitro: PD173074 is an ATP-competitive inhibitor of FGFR1 with Ki of ~40 nM. PD173074 is also an effective inhibitor of VEGFR2. Compared to FGFR1, PD173074 weakly inhibits the activities of Src, InsR, EGFR, PDGFR, MEK, and PKC with 1000-fold or greater IC50 values. PD173074 inhibits autophosphorylation of FGFR1 and VEGFR2 in a dose-dependent manner with IC50 of 1-5 nM and 100-200 nM, respectively[1]. PD173074 inhibits FGF-2 promotion of granule neuron survival in a dose-dependent manner with IC50 of 12 nM, exhibiting 1,000-fold greater potency than that of SU 5402 [2]. PD173074 specifically inhibits FGF-2-mediated effects on proliferation, differentiation, and MAPK activation in oligodendrocyte (OL) lineage cells [3].;In vivo: Administration of PD173 MedChem Express HY-10321
      Protein Tyrosine Kinase/RTK MedChem Express HY-10321
      Protein Tyrosine Kinase/RTK; MedChem Express HY-10321
      Receptor Tyrosine Kinases (RTKs) Tocris Bioscience 3044
      Receptors & Transporters/Enzyme-linked (Catalytic)/RTK/FGFR Hello Bio HB3584
      Selective FGFR1 and FGFR3 inhibitor (IC50 values are 5, 21.5, ~100, 17600 and 19800 nM for FGFR3, FGFR1, VEGFR2, PDGFR and c-Src respectively, and > 50000 nM for EGFR, InsR, MEK and PKC). Inhibits VEG F- and FGF-induced angiogenesis in the mouse cornea model of angiogenesis. Inhibits proliferation and differentiation of oligodendrocyte progenitors. Suppresses cell proliferation in cell lines expres sing mutated FGFR3 protein. Blocks tumor growth in H510 and H69 SCLC xenograft models. Tocris Bioscience 3044
      Selective FGFR1 and FGFR3 inhibitor (IC50 values are 5, 21.5, ~100, 17600 and 19800 nM for FGFR3, FGFR1, VEGFR2, PDGFR and c-Src respectively, and > 50000 nM for EGFR, InsR, MEK and PKC). Inhibits VEGF- and FGF-induced angiogenesis in the mouse cornea model of angiogenesis. Inhibits proliferation and differentiation of oligodendrocyte progenitors. Suppresses cell proliferation in cell lines expressing mutated FGFR3 protein. Blocks tumor growth in H510 and H69 SCLC xenograft models. Tocris Bioscience 3044
      Tyrosine Kinase/Adaptors TargetMol T2642

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.2±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.599
Molar Refractivity: 153.8±0.3 cm3
#H bond acceptors: 10
#H bond donors: 3
#Freely Rotating Bonds: 13
#Rule of 5 Violations: 2
ACD/LogP: 3.33
ACD/LogD (pH 5.5): 0.91
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 2.90
ACD/LogD (pH 7.4): 1.23
ACD/BCF (pH 7.4): 1.09
ACD/KOC (pH 7.4): 6.01
Polar Surface Area: 114 Å2
Polarizability: 61.0±0.5 10-24cm3
Surface Tension: 48.7±3.0 dyne/cm
Molar Volume: 450.2±3.0 cm3

Click to predict properties on the Chemicalize site


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