ChemSpider 2D Image | GSK269962 | C29H30N8O5

GSK269962

  • Molecular FormulaC29H30N8O5
  • Average mass570.599 Da
  • Monoisotopic mass570.233887 Da
  • ChemSpider ID17253632

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

850664-21-0 [RN]
GSK 269962
GSK269962
GSK269962A
N-(3-{[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy}phenyl)-4-[2-(morpholin-4-yl)ethoxy]benzamide
N-(3-{[2-(4-AMINO-1,2,5-OXADIAZOL-3-YL)-1-ETHYLIMIDAZO[4,5-C]PYRIDIN-6-YL]OXY}PHENYL)-4-[2-(MORPHOLIN-4-YL)ETHOXY]BENZAMIDE
[850664-21-0] [RN]
850664-21-0 (free base)
925213-63-4 [RN]
Aminofurazanyl-azabenzimidazole 6n
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

CCRIS 4693 [DBID]
  • Experimental Physico-chemical Properties

    • Experimental Solubility:

      DMSO:48mg/mL; MedChem Express HY-15556
      Soluble to 100 mM in DMSO and to 10 mM in ethanol Tocris Bioscience 4009
      Soluble to 100 mM in DMSO and to 10 mM in ethanol MedChem Express HY-15556
      Soluble to 100 mM in DMSO and to 10 mM in ethanol with gentle warming Tocris Bioscience 4009
      Soluble to 100 mM in DMSO and to 50 mM in ethanol Tocris Bioscience 4009
  • Miscellaneous

    • Safety:

      Sold for research purposes under agreement from GlaxoSmithKline. Tocris Bioscience 4009

    • Bio Activity:

      Cell Cycle/DNA Damage MedChem Express HY-15556
      Cell Cycle/DNA Damage; TGF-beta/Smad; MedChem Express HY-15556
      Enzymes Tocris Bioscience 4009
      GSK269962A(GSK269962) is a potent ROCK inhibitor (IC50 values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively); displays greater than 30-fold selectivity for ROCK against a panel o f serine/threonine kinases. MedChem Express
      GSK269962A(GSK269962) is a potent ROCK inhibitor (IC50 values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively); displays greater than 30-fold selectivity for ROCK against a panel of serine/threonine kinases.; IC50 value: 1.6 nM/4 nM (ROCK1/2) [1]; Target: ROCK1/2; GSK269962A induces vasorelaxation in preconstricted rat aorta (IC50 = 35 nM); lowers blood pressure in a rat model of hypertension; At doses of 1, 3, and 30 mg/kg, GSK269962A induced a reduction in blood pressure of approximately 10, 20, and 50 mm Hg. MedChem Express HY-15556
      GSK269962A(GSK269962) is a potent ROCK inhibitor (IC50 values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively); displays greater than 30-fold selectivity for ROCK against a panel of serine/threonine kinases.;IC50 value: 1.6 nM/4 nM (ROCK1/2) [1];Target: ROCK1/2GSK269962A induces vasorelaxation in preconstricted rat aorta (IC50 = 35 nM); lowers blood pressure in a rat model of hypertension; At doses of 1, 3, and 30 mg/kg, GSK269962A induced a reduction in blood pressure of approximately 10, 20, and 50 mm Hg. GSK269962A represent a novel class of ROCK inhibitors that have profound effects in the vasculature and may enable us to further evaluate the potential beneficial effects of ROCK inhibition in animal models of cardiovascular as well as other chronic diseases. MedChem Express HY-15556
      Kinases Tocris Bioscience 4009
      Potent and selective ROCK inhibitor Tocris Bioscience 4009
      Potent Rho kinase (ROCK) inhibitor (IC50 values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively). Displays greater than 30-fold selectivity for ROCK against a panel of serine/threo nine kinases. Induces vasorelaxation in preconstricted rat aorta (IC50 = 35 nM); lowers blood pressure in a rat model of hypertension. Tocris Bioscience 4009
      Potent Rho kinase (ROCK) inhibitor (IC50 values are 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively). Displays greater than 30-fold selectivity for ROCK against a panel of serine/threonine kinases. Induces vasorelaxation in preconstricted rat aorta (IC50 = 35 nM); lowers blood pressure in a rat model of hypertension. Tocris Bioscience 4009
      Rho-kinases Tocris Bioscience 4009
      ROCK MedChem Express HY-15556

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.5±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.705
Molar Refractivity: 152.2±0.5 cm3
#H bond acceptors: 13
#H bond donors: 3
#Freely Rotating Bonds: 10
#Rule of 5 Violations: 2
ACD/LogP: 4.74
ACD/LogD (pH 5.5): 2.33
ACD/BCF (pH 5.5): 20.88
ACD/KOC (pH 5.5): 168.71
ACD/LogD (pH 7.4): 3.21
ACD/BCF (pH 7.4): 157.96
ACD/KOC (pH 7.4): 1276.17
Polar Surface Area: 156 Å2
Polarizability: 60.3±0.5 10-24cm3
Surface Tension: 60.9±7.0 dyne/cm
Molar Volume: 391.7±7.0 cm3

Click to predict properties on the Chemicalize site


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