ChemSpider 2D Image | PF-04217903 | C19H16N8O

PF-04217903

  • Molecular FormulaC19H16N8O
  • Average mass372.383 Da
  • Monoisotopic mass372.144714 Da
  • ChemSpider ID21437054

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1H-Pyrazole-1-ethanol, 4-[1-(6-quinolinylmethyl)-1H-1,2,3-triazolo[4,5-b]pyrazin-6-yl]- [ACD/Index Name]
2-(4-{1-[(quinolin-6-yl)methyl]-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl}-1H-pyrazol-1-yl)ethan-1-ol
2-{4-[1-(6-Chinolinylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazol-1-yl}ethanol [German] [ACD/IUPAC Name]
2-{4-[1-(6-Quinoléinylméthyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazol-1-yl}éthanol [French] [ACD/IUPAC Name]
2-{4-[1-(6-Quinolinylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazol-1-yl}ethanol [ACD/IUPAC Name]
2-{4-[3-(QUINOLIN-6-YLMETHYL)-[1,2,3]TRIAZOLO[4,5-B]PYRAZIN-5-YL]PYRAZOL-1-YL}ETHANOL
956905-27-4 [RN]
PF-04217903
[956905-27-4] [RN]
1159490-85-3 [RN]
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

CYJ9ATV1IJ [DBID]
UNII:CYJ9ATV1IJ [DBID]
UNII-CYJ9ATV1IJ [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Target Organs:

      c-Met inhibitor TargetMol T2676

    • Bio Activity:

      c-Met TargetMol T2676
      c-Met/HGFR MedChem Express HY-12017
      PF-04217903 is a selective ATP-competitive c-Met inhibitor with IC50 of 4.8 nM, susceptible to oncogenic mutations (no activity to Y1230C mutant). MedChem Express
      PF-04217903 is a selective ATP-competitive c-Met inhibitor with IC50 of 4.8 nM, susceptible to oncogenic mutations (no activity to Y1230C mutant).; IC50 value: 4.8 nM [1]; Target: ; in vitro: Being more selective than staurosporine or PF-02341066, PF-04217903 displays >1000-fold selectivity for c-Met over a panel of 208 kinases, although more susceptible to oncogenic mutations of c-Met that attenuate potency than PF-02341066. MedChem Express HY-12017
      Protein Tyrosine Kinase/RTK MedChem Express HY-12017
      Protein Tyrosine Kinase/RTK; MedChem Express HY-12017
      Tyrosine Kinase/Adaptors TargetMol T2676

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.5±0.1 g/cm3
Boiling Point: 718.1±60.0 °C at 760 mmHg
Vapour Pressure: 0.0±2.4 mmHg at 25°C
Enthalpy of Vaporization: 110.2±3.0 kJ/mol
Flash Point: 388.1±32.9 °C
Index of Refraction: 1.807
Molar Refractivity: 104.5±0.5 cm3
#H bond acceptors: 9
#H bond donors: 1
#Freely Rotating Bonds: 5
#Rule of 5 Violations: 0
ACD/LogP: 0.30
ACD/LogD (pH 5.5): 1.32
ACD/BCF (pH 5.5): 5.77
ACD/KOC (pH 5.5): 117.49
ACD/LogD (pH 7.4): 1.38
ACD/BCF (pH 7.4): 6.60
ACD/KOC (pH 7.4): 134.27
Polar Surface Area: 107 Å2
Polarizability: 41.4±0.5 10-24cm3
Surface Tension: 71.6±7.0 dyne/cm
Molar Volume: 242.9±7.0 cm3

Click to predict properties on the Chemicalize site


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