ChemSpider 2D Image | Tenovin-6 | C25H34N4O2S

Tenovin-6

  • Molecular FormulaC25H34N4O2S
  • Average mass454.628 Da
  • Monoisotopic mass454.240234 Da
  • ChemSpider ID21467838

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1011557-82-6 [RN]
Benzamide, N-[[[4-[[5-(dimethylamino)-1-oxopentyl]amino]phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)- [ACD/Index Name]
N-[(4-{[5-(Dimethylamino)pentanoyl]amino}phenyl)carbamothioyl]-4-(2-methyl-2-propanyl)benzamid [German] [ACD/IUPAC Name]
N-[(4-{[5-(Dimethylamino)pentanoyl]amino}phenyl)carbamothioyl]-4-(2-methyl-2-propanyl)benzamide [ACD/IUPAC Name]
N-[(4-{[5-(Diméthylamino)pentanoyl]amino}phényl)carbamothioyl]-4-(2-méthyl-2-propanyl)benzamide [French] [ACD/IUPAC Name]
N-[4-({[(4-TERT-BUTYLPHENYL)FORMAMIDO]METHANETHIOYL}AMINO)PHENYL]-5-(DIMETHYLAMINO)PENTANAMIDE
Tenovin-6
[1011557-82-6] [RN]
2-(Benzo[b]thiophen-5-yl)acetic acid
4-(tert-butyl)-N-((4-(5-(dimethylamino)pentanamido)phenyl)carbamothioyl)benzamide
More...
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Target Organs:

      p53 activator; sirtuin inhibitor TargetMol T1818

    • Chemical Class:

      A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-(dimethylamino)pentanoic acid with the aromatic amino group of <element>N</element>-[(4-aminophenyl)carbamothioyl] -4-<ital>tert</ital>-butylbenzamide. ChEBI CHEBI:77729
      A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-(dimethylamino)pentanoic acid with the aromatic amino group of N-[(4-aminophenyl)carbamothioyl]; -4-tert-butylbenz amide. ChEBI https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:77729
      A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-(dimethylamino)pentanoic acid with the aromatic amino group of N-[(4-aminophenyl)carbamothioyl]-4-tert-butylbenzam ide. ChEBI CHEBI:77729

    • Bio Activity:

      Apoptosis TargetMol T1818
      Cell Cycle/DNA Damage MedChem Express HY-15510
      Cell Cycle/DNA Damage; MedChem Express HY-15510
      p53;Sirt1/2/3 TargetMol T1818
      Sirtuin MedChem Express HY-15510
      Tenovin-6 is the water soluble analog of Tenovin-1 (HY-13423) and acts as a potent SIRT1 (IC50=21 uM) and SIRT2 (IC50= 10 uM) inhibitor as well as p53 activator. MedChem Express
      Tenovin-6 is the water soluble analog of Tenovin-1 (HY-13423) and acts as a potent SIRT1 (IC50=21 uM) and SIRT2 (IC50= 10 uM) inhibitor as well as p53 activator.; IC50 value: 21 uM (human SIRT1); 10 uM (human SIRT2) [1]; Target: SIRT1; SIRT2; in vitro: Tenovin-6 inhibits the growth of S. MedChem Express HY-15510

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.2±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.617
Molar Refractivity: 135.9±0.3 cm3
#H bond acceptors: 6
#H bond donors: 3
#Freely Rotating Bonds: 11
#Rule of 5 Violations: 0
ACD/LogP: 3.64
ACD/LogD (pH 5.5): 0.46
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 1.71
ACD/LogD (pH 7.4): 1.39
ACD/BCF (pH 7.4): 2.08
ACD/KOC (pH 7.4): 14.72
Polar Surface Area: 106 Å2
Polarizability: 53.9±0.5 10-24cm3
Surface Tension: 51.0±3.0 dyne/cm
Molar Volume: 388.2±3.0 cm3

Click to predict properties on the Chemicalize site


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