ChemSpider 2D Image | Ro 08-2750 | C13H10N4O3

Ro 08-2750

  • Molecular FormulaC13H10N4O3
  • Average mass270.243 Da
  • Monoisotopic mass270.075287 Da
  • ChemSpider ID21475107

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

37854-59-4 [RN]
7,10-Dimethyl-2,4-dioxo-2,3,4,10-tetrahydrobenzo[g]pteridin-8-carbaldehyd [German] [ACD/IUPAC Name]
7,10-Dimethyl-2,4-dioxo-2,3,4,10-tetrahydrobenzo[g]pteridine-8-carbaldehyde [ACD/IUPAC Name]
7,10-Diméthyl-2,4-dioxo-2,3,4,10-tétrahydrobenzo[g]ptéridine-8-carbaldéhyde [French] [ACD/IUPAC Name]
7,10-dimethyl-2,4-dioxo-8-benzo[g]pteridinecarboxaldehyde
Benzo[g]pteridine-8-carboxaldehyde, 2,3,4,10-tetrahydro-7,10-dimethyl-2,4-dioxo- [ACD/Index Name]
Ro 08-2750
[37854-59-4] [RN]
2,3,4,10-tetrahydro-7,10-dimethyl-2,4-dioxo-benzo[g]pteridine-8-carboxaldehyde
2,3,4,10-Tetrahydro-7,10-dimethyl-2,4-dioxobenzo[g]pteridine-8-carboxaldehyde
More...
  • Experimental Physico-chemical Properties

    • Experimental Solubility:

      Soluble to 10 mM in DMSO with gentle warming Tocris Bioscience 2272
      Soluble to 50 mM in 1eq. NaOH and to 10 mM in DMSO Tocris Bioscience 2272
      Soluble to 50 mM in 1eq. NaOH and to 10 mM in DMSO with gentle warming Tocris Bioscience 2272
  • Miscellaneous

    • Bio Activity:

      Enzyme-Linked Receptors Tocris Bioscience 2272
      Inhibits NGF binding to p75NTR and TrkA Tocris Bioscience 2272
      Non-peptide inhibitor of NGF that binds the NGF dimer (KD ~ 1 ?M) possibly causing a conformational change. Selectively inhibits binding of NGF to p75NTR at submicromolar concentrations, and to both p 75NTR and TrkA at concentrations > 5 ?M. Prevents NGF-induced apoptosis in SK-N-MC cells. Tocris Bioscience 2272
      Non-peptide inhibitor of NGF that binds the NGF dimer (KD ~ 1 ?M) possibly causing a conformational change. Selectively inhibits binding of NGF to p75NTR at submicromolar concentrations, and to both p75NTR and TrkA at concentrations > 5 ?M. Prevents NGF-induced apoptosis in SK-N-MC cells. Tocris Bioscience 2272
      Non-peptide inhibitor of NGF that binds the NGF dimer (KD ~ 1 muM) possibly causing a conformational change. Selectively inhibits binding of NGF to p75NTR at submicromolar concentrations, and to both p75NTR and TrkA at concentrations > 5 muM. Prevents NGF-induced apoptosis in SK-N-MC cells. Tocris Bioscience 2272
      Receptor Tyrosine Kinases (RTKs) Tocris Bioscience 2272
      Trk Receptors Tocris Bioscience 2272

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.6±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.754
Molar Refractivity: 70.1±0.5 cm3
#H bond acceptors: 7
#H bond donors: 1
#Freely Rotating Bonds: 1
#Rule of 5 Violations: 0
ACD/LogP: -0.81
ACD/LogD (pH 5.5): -0.03
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 23.08
ACD/LogD (pH 7.4): -0.03
ACD/BCF (pH 7.4): 1.00
ACD/KOC (pH 7.4): 22.98
Polar Surface Area: 91 Å2
Polarizability: 27.8±0.5 10-24cm3
Surface Tension: 65.3±7.0 dyne/cm
Molar Volume: 171.4±7.0 cm3

Click to predict properties on the Chemicalize site


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