ChemSpider 2D Image | GSK650394 | C25H22N2O2

GSK650394

  • Molecular FormulaC25H22N2O2
  • Average mass382.454 Da
  • Monoisotopic mass382.168121 Da
  • ChemSpider ID24606024

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoesäure [German] [ACD/IUPAC Name]
2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid [ACD/IUPAC Name]
2-cyclopentyl-4-{5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl}benzoic acid
890842-28-1 [RN]
Acide 2-cyclopentyl-4-(5-phényl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoïque [French] [ACD/IUPAC Name]
Benzoic acid, 2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)- [ACD/Index Name]
GSK650394
GSK-650394
[890842-28-1] [RN]
2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-benzoic acid
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

56887611DJ [DBID]
UNII:56887611DJ [DBID]
UNII-56887611DJ [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Safety:

      Sold with the permission of GlaxoSmithKline Tocris Bioscience 3572

    • Target Organs:

      SGK inhibitor TargetMol T2622

    • Bio Activity:

      Enzymes Tocris Bioscience 3572
      GSK650394 is a novel SGK inhibitor with IC50 of 62 nM and 103 nM for SGK1 and SGK2 in the SPA assay respectively. MedChem Express http://www.medchemexpress.com/GDC-0068.html, HY-15192
      Kinases Tocris Bioscience 3572
      Other Kinases Tocris Bioscience 3572
      Others MedChem Express HY-15192
      Others TargetMol T2622
      Serum- and glucocorticoid-regulated kinase (SGK) inhibitor Tocris Bioscience 3572
      Serum- and glucocorticoid-regulated kinase 1 (SGK1) inhibitor (IC50 values are 62 and 103 nM for SGK1 and SGK2 respectively). Displays >30-fold selectivity over Akt and other related kinases. Inhibits androgen-stimulated growth of LNCaP cells, a human prostate carcinoma cell line (IC50 ~ 1 ?M). Tocris Bioscience 3572
      Serum- and glucocorticoid-regulated kinase 1 (SGK1) inhibitor (IC50 values are 62 and 103 nM for SGK1 and SGK2 respectively). Displays >30-fold selectivity over Akt and other related kinases. Inhibits androgen-stimulated growth of LNCaP cells, a human prostate carcinoma cell line (IC50 ~ 1 muM). Tocris Bioscience 3572
      Serum- and glucocorticoid-regulated kinase 1 (SGK1) inhibitor (IC50 values are 62 and 103 nM for SGK1 and SGK2 respectively). Displays >30-fold selectivity over Akt and other related kinases. Inhibits androgen-stimulated growth of LNCaP cells, a human prostate carcinoma cell line (IC50 ~ 1 ?M). Tocris Bioscience 3572
      SGK MedChem Express HY-15192
      SGK1;SGK2 TargetMol T2622

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.3±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.680
Molar Refractivity: 114.0±0.3 cm3
#H bond acceptors: 4
#H bond donors: 2
#Freely Rotating Bonds: 4
#Rule of 5 Violations: 1
ACD/LogP: 6.95
ACD/LogD (pH 5.5): 4.98
ACD/BCF (pH 5.5): 1692.90
ACD/KOC (pH 5.5): 2900.07
ACD/LogD (pH 7.4): 3.48
ACD/BCF (pH 7.4): 53.38
ACD/KOC (pH 7.4): 91.44
Polar Surface Area: 66 Å2
Polarizability: 45.2±0.5 10-24cm3
Surface Tension: 60.1±3.0 dyne/cm
Molar Volume: 301.7±3.0 cm3

Click to predict properties on the Chemicalize site


Advertisement