ChemSpider 2D Image | SGX 523 | C18H13N7S

SGX 523

  • Molecular FormulaC18H13N7S
  • Average mass359.408 Da
  • Monoisotopic mass359.095306 Da
  • ChemSpider ID24608644

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1022150-57-7 [RN]
6-[[6-(1-methyl-1h-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]quinoline
6-{[6-(1-Methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}chinolin [German] [ACD/IUPAC Name]
6-{[6-(1-Méthyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoléine [French] [ACD/IUPAC Name]
6-{[6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline
6-{[6-(1-Methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline [ACD/IUPAC Name]
6-{[6-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline
Quinoline, 6-[[6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]- [ACD/Index Name]
SGX 523
SGX523
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

CCRIS 4693 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Target Organs:

      c-Met inhibitor; Raf inhibitor; Bcr-Abl inhibitor; p38 MAPK inhibitor TargetMol T2293

    • Chemical Class:

      A member of the class of triazolopyridazines that is 6-(1-methylpyrazol-4-yl)[1,2,4]triazolo[4,3-<ital>b</ital>]pyridazine-3-thiol in which the thiol hydrogen is replaced by a quinolin-6-yl group. ChEBI CHEBI:90624
      A member of the class of triazolopyridazines that is 6-(1-methylpyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazine-3-thiol in which the thiol hydrogen is replaced by a quinolin-6-yl group. ChEBI CHEBI:90624

    • Bio Activity:

      c-Met/HGFR MedChem Express HY-12019
      c-Met;B-Raf/C-Raf/Abl/p38?? TargetMol T2293
      Enzyme-Linked Receptors Tocris Bioscience 5356
      MET Receptors Tocris Bioscience 5356
      Potent and selective c-MET kinase inhibitor (IC50 = 4nM). Exhibits minimal inhibition against a panel of 213 other protein kinases (at 1 ?M). Suppresses growth of tumor xenografts derived from human g lioblastoma, lung and gastric cancer cells. Tocris Bioscience 5356
      Potent and selective c-MET kinase inhibitor (IC50 = 4nM). Exhibits minimal inhibition against a panel of 213 other protein kinases (at 1 ?M). Suppresses growth of tumor xenografts derived from human glioblastoma, lung and gastric cancer cells. Tocris Bioscience 5356
      Potent and selective c-MET kinase inhibitor (IC50 = 4nM). Exhibits minimal inhibition against a panel of 213 other protein kinases (at 1 muM). Suppresses growth of tumor xenografts derived from human glioblastoma, lung and gastric cancer cells. Tocris Bioscience 5356
      Protein Tyrosine Kinase/RTK MedChem Express HY-12019
      Protein Tyrosine Kinase/RTK; MedChem Express HY-12019
      Receptor Tyrosine Kinases (RTKs) Tocris Bioscience 5356
      Selective and potent c-MET kinase inhibitor Tocris Bioscience 5356
      SGX-523 is a selective Met inhibitor with IC50 of 4 nM, no activity to BRAFV599E, c-Raf, Abl and p38?.; IC50 value: 4 nM [1]; Target: Met; in vitro: SGX-523 belongs to the class of c-Met/hepatocyte growth factor receptor (HGFR) tyrosine kinase inhibitors. MedChem Express HY-12019
      Tyrosine Kinase/Adaptors;Angiogensis; MAPK Signaling TargetMol T2293

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.5±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.817
Molar Refractivity: 103.6±0.5 cm3
#H bond acceptors: 7
#H bond donors: 0
#Freely Rotating Bonds: 3
#Rule of 5 Violations: 0
ACD/LogP: 2.73
ACD/LogD (pH 5.5): 2.12
ACD/BCF (pH 5.5): 23.84
ACD/KOC (pH 5.5): 334.34
ACD/LogD (pH 7.4): 2.13
ACD/BCF (pH 7.4): 24.48
ACD/KOC (pH 7.4): 343.31
Polar Surface Area: 99 Å2
Polarizability: 41.1±0.5 10-24cm3
Surface Tension: 67.8±7.0 dyne/cm
Molar Volume: 238.5±7.0 cm3

Click to predict properties on the Chemicalize site


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