ChemSpider 2D Image | 8-[3,5-difluoro-4-(morpholin-4-ylmethyl)phenyl]-2-[1-(piperidin-4-yl)pyrazol-4-yl]quinoxaline | C27H28F2N6O

8-[3,5-difluoro-4-(morpholin-4-ylmethyl)phenyl]-2-[1-(piperidin-4-yl)pyrazol-4-yl]quinoxaline

  • Molecular FormulaC27H28F2N6O
  • Average mass490.548 Da
  • Monoisotopic mass490.229279 Da
  • ChemSpider ID24669069

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1092499-93-8 [RN]
8-[3,5-Difluor-4-(4-morpholinylmethyl)phenyl]-2-[1-(4-piperidinyl)-1H-pyrazol-4-yl]chinoxalin [German] [ACD/IUPAC Name]
8-[3,5-Difluoro-4-(4-morpholinylmethyl)phenyl]-2-[1-(4-piperidinyl)-1H-pyrazol-4-yl]quinoxaline [ACD/IUPAC Name]
8-[3,5-Difluoro-4-(4-morpholinylméthyl)phényl]-2-[1-(4-pipéridinyl)-1H-pyrazol-4-yl]quinoxaline [French] [ACD/IUPAC Name]
8-[3,5-Difluoro-4-(Morpholin-4-Ylmethyl)phenyl]-2-(1-Piperidin-4-Yl-1h-Pyrazol-4-Yl)quinoxaline
8-[3,5-difluoro-4-(morpholin-4-ylmethyl)phenyl]-2-[1-(piperidin-4-yl)pyrazol-4-yl]quinoxaline
8-{3,5-difluoro-4-[(morpholin-4-yl)methyl]phenyl}-2-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]quinoxaline
Quinoxaline, 8-[3,5-difluoro-4-(4-morpholinylmethyl)phenyl]-2-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- [ACD/Index Name]
[1092499-93-8] [RN]
4-(2,6-difluoro-4-(3-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)quinoxalin-5-yl)benzyl)morpholine
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  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      JAK MedChem Express HY-14722
      JAK/STAT Signaling MedChem Express HY-14722
      JAK/STAT Signaling; MedChem Express HY-14722
      NVP-BSK805 is a potent and selective ATP-competitive JAK2 inhibitor with IC50 of 0.5 nM; MedChem Express http://www.medchemexpress.com/EMD-1214063.html
      NVP-BSK805 is a potent and selective ATP-competitive JAK2 inhibitor with IC50 of 0.5 nM; >20-fold selectivity towards JAK1, JAK3 and TYK2.; IC50 Value: 0.48 ? 0.02 nM (JAK2 JH1); 0.58 ? 0.03 nM (FL JAK2 wt) [1]; Target: JAK2; in vitro: NVP-BSK805 is found to potently inhibit JAK2, whereas displaying more than 20-fold selectivity towards JAK1, JAK3, and TYK2. MedChem Express HY-14722

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.4±0.1 g/cm3
Boiling Point: 639.8±55.0 °C at 760 mmHg
Vapour Pressure: 0.0±1.9 mmHg at 25°C
Enthalpy of Vaporization: 94.5±3.0 kJ/mol
Flash Point: 340.7±31.5 °C
Index of Refraction: 1.689
Molar Refractivity: 132.9±0.5 cm3
#H bond acceptors: 7
#H bond donors: 1
#Freely Rotating Bonds: 5
#Rule of 5 Violations: 0
ACD/LogP: 1.38
ACD/LogD (pH 5.5): -0.93
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 1.00
ACD/LogD (pH 7.4): -0.04
ACD/BCF (pH 7.4): 1.00
ACD/KOC (pH 7.4): 2.00
Polar Surface Area: 68 Å2
Polarizability: 52.7±0.5 10-24cm3
Surface Tension: 51.9±7.0 dyne/cm
Molar Volume: 348.3±7.0 cm3

Click to predict properties on the Chemicalize site


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