ChemSpider 2D Image | AZD6482 | C22H24N4O4

AZD6482

  • Molecular FormulaC22H24N4O4
  • Average mass408.450 Da
  • Monoisotopic mass408.179749 Da
  • ChemSpider ID24747351

  • defined stereocentres - 1 of 1 defined stereocentres

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1173900-33-8 [RN]
2-({(1R)-1-[7-Methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl}amino)benzoesäure [German] [ACD/IUPAC Name]
2-({(1R)-1-[7-Methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl}amino)benzoic acid [ACD/IUPAC Name]
2-{[(1R)-1-[7-methyl-2-(morpholin-4-yl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino}benzoic acid
2-{[(1R)-1-[7-methyl-2-(morpholin-4-yl)-4-oxopyrido[1,2-a]pyrimidin-9-yl]ethyl]amino}benzoic acid
78G6MP5PZ5
Acide 2-({(1R)-1-[7-méthyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]éthyl}amino)benzoïque [French] [ACD/IUPAC Name]
AZD6482
Benzoic acid, 2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]- [ACD/Index Name]
(R)-2-((1-(7-methyl-2-morpholino-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl)ethyl)amino)benzoic acid
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

CCRIS 4693 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Safety:

      Sold with the permission of AstraZeneca UK Ltd. Tocris Bioscience 4839

    • Bio Activity:

      AZD6482 is a PI3K? inhibitor with IC50 of 10 nM, 8-, 87- and 109-fold more selective to PI3K? than PI3K?, PI3K? and PI3K?.; IC50 value: 10 nM; Target: PI3K?; AZD6482 is a PI3K? inhibitor (IC50=0.021?M) used in antithrombotic therapy. MedChem Express HY-10344
      Enzymes Tocris Bioscience 4839
      Kinases Tocris Bioscience 4839
      PI 3-Kinase Tocris Bioscience 4839
      PI3K MedChem Express HY-10344
      PI3K/Akt/mTOR MedChem Express HY-10344
      PI3K/Akt/mTOR ; MedChem Express HY-10344
      Potent and selective inhibitor of PI 3-kinase ? (PI 3-K?) (IC50 values are 0.69, 13.6, 47.8 and 136 nM for PI 3-K?, PI 3-K?, PI 3-K? and PI 3-K?, respectively). Selectively inhibits in vivo growth of the PTEN-deficient tumor xenografts HCC70 and PC3. Also exhibits antithrombotic activity. Tocris Bioscience 4839
      Potent and selective inhibitor of PI 3-kinase ? (PI 3-K?) (IC50 values are 0.69, 13.6, 47.8 and 136 nM for PI 3-K?, PI 3-K?, PI 3-K? and PI 3-K?, respectively). Selectively inhibits in vivo growth of the PTEN-deficient tumor xenografts HCC70 and PC3. Also exhibits antithrombotic activity. Tocris Bioscience 4839
      Potent and selective inhibitor of PI 3-kinase beta (PI 3-Kbeta) (IC50 values are 0.69, 13.6, 47.8 and 136 nM for PI 3-Kbeta, PI 3-Kdelta, PI 3-Kgamma and PI 3-Kalpha, respectively). Selectively inhibits in vivo growth of the PTEN-deficient tumor xenografts HCC70 and PC3. Also exhibits antithrombotic activity. Tocris Bioscience 4839
      Potent and selective PI 3-K? inhibitor Tocris Bioscience 4839
      Potent and selective PI 3-Kbeta inhibitor Tocris Bioscience 4839

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.4±0.1 g/cm3
Boiling Point: 635.5±65.0 °C at 760 mmHg
Vapour Pressure: 0.0±2.0 mmHg at 25°C
Enthalpy of Vaporization: 98.7±3.0 kJ/mol
Flash Point: 338.1±34.3 °C
Index of Refraction: 1.664
Molar Refractivity: 111.3±0.5 cm3
#H bond acceptors: 8
#H bond donors: 2
#Freely Rotating Bonds: 5
#Rule of 5 Violations: 0
ACD/LogP: 4.07
ACD/LogD (pH 5.5): 1.49
ACD/BCF (pH 5.5): 3.45
ACD/KOC (pH 5.5): 31.43
ACD/LogD (pH 7.4): 0.04
ACD/BCF (pH 7.4): 1.00
ACD/KOC (pH 7.4): 1.13
Polar Surface Area: 94 Å2
Polarizability: 44.1±0.5 10-24cm3
Surface Tension: 54.0±7.0 dyne/cm
Molar Volume: 300.1±7.0 cm3

Click to predict properties on the Chemicalize site


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