ChemSpider 2D Image | BIX02188 | C25H24N4O2

BIX02188

  • Molecular FormulaC25H24N4O2
  • Average mass412.484 Da
  • Monoisotopic mass412.189911 Da
  • ChemSpider ID24764932

  • Double-bond stereo - Double-bond stereo

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(3Z)-3-[({3-[(Dimethylamino)methyl]phenyl}amino)(phenyl)methylen]-2-oxo-6-indolincarboxamid [German] [ACD/IUPAC Name]
(3Z)-3-[({3-[(Dimethylamino)methyl]phenyl}amino)(phenyl)methylene]-2-oxo-6-indolinecarboxamide [ACD/IUPAC Name]
(3Z)-3-[({3-[(Diméthylamino)méthyl]phényl}amino)(phényl)méthylène]-2-oxo-6-indolinecarboxamide [French] [ACD/IUPAC Name]
(3Z)-3-[({3-[(DIMETHYLAMINO)METHYL]PHENYL}AMINO)(PHENYL)METHYLIDENE]-2-OXO-1H-INDOLE-6-CARBOXAMIDE
(3Z)-3-[({3-[(dimethylamino)methyl]phenyl}amino)(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxamide
1094614-84-2 [RN]
1H-Indole-6-carboxamide, 3-[[[3-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-, (3Z)- [ACD/Index Name]
3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indole-6-carboxamide
334949-59-6 [RN]
4Y3VYY2X83
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

PubChem Substance ID 329825761 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      BIX02188 is a selective inhibitor of MEK5 with IC50 of 4.3 nM, also inhibits ERK5 catalytic activity with IC50 of 810 nM, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2.; IC50 value: 4.3 nM; Target: MEK5; in vitro: BIX02188 significantly blocks MEK5 catalytic activity with IC50 of 4.3 nM and inhibits ERK5 catalytic activity with IC50 of 0.83 ?M. MedChem Express HY-12055
      MAPK MedChem Express HY-12055
      MAPK ; MedChem Express HY-12055
      MEK MedChem Express HY-12055

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.3±0.1 g/cm3
Boiling Point: 615.8±55.0 °C at 760 mmHg
Vapour Pressure: 0.0±1.8 mmHg at 25°C
Enthalpy of Vaporization: 91.3±3.0 kJ/mol
Flash Point: 326.2±31.5 °C
Index of Refraction: 1.688
Molar Refractivity: 122.6±0.3 cm3
#H bond acceptors: 6
#H bond donors: 4
#Freely Rotating Bonds: 6
#Rule of 5 Violations: 0
ACD/LogP: 2.36
ACD/LogD (pH 5.5): -0.14
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 1.00
ACD/LogD (pH 7.4): 1.32
ACD/BCF (pH 7.4): 2.67
ACD/KOC (pH 7.4): 27.28
Polar Surface Area: 87 Å2
Polarizability: 48.6±0.5 10-24cm3
Surface Tension: 61.5±3.0 dyne/cm
Molar Volume: 321.3±3.0 cm3

Click to predict properties on the Chemicalize site


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