ChemSpider 2D Image | SCH-1473759 | C20H26N8OS

SCH-1473759

  • Molecular FormulaC20H26N8OS
  • Average mass426.538 Da
  • Monoisotopic mass426.195038 Da
  • ChemSpider ID25061000

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1094069-99-4 [RN]
1-Propanol, 2-[ethyl[[5-[[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]-3-isothiazolyl]methyl]amino]-2-methyl- [ACD/Index Name]
2-{Ethyl[(5-{[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}-1,2-thiazol-3-yl)methyl]amino}-2-methyl-1-propanol [German] [ACD/IUPAC Name]
2-{Ethyl[(5-{[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}-1,2-thiazol-3-yl)methyl]amino}-2-methyl-1-propanol [ACD/IUPAC Name]
2-{Éthyl[(5-{[6-méthyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}-1,2-thiazol-3-yl)méthyl]amino}-2-méthyl-1-propanol [French] [ACD/IUPAC Name]
2-{Ethyl[(5-{[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}-1,2-thiazol-3-yl)methyl]amino}-2-methylpropan-1-ol
2-{ethyl[(5-{[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}isothiazol-3-yl)methyl]amino}-2-methylpropan-1-ol
SCH-1473759
[1094069-99-4] [RN]
1-Propanol,2-[ethyl[[5-[[6-Methyl-3-(1H-pyrazol-4-yl)iMidazo[1,2-a]pyrazin-8-yl]aMino]-3-isothiazolyl]Methyl]aMino]-2-Methyl-
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  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      Aurora Kinase MedChem Express HY-10482
      Cell Cycle/DNA Damage MedChem Express HY-10482
      Cell Cycle/DNA Damage; MedChem Express HY-10482
      SCH 1473759 is a novel sub-nanomolar Aurora A/B inhibitor with IC50 of 4 nM and 13 nM, respectively. MedChem Express
      SCH 1473759 is a novel sub-nanomolar Aurora A/B inhibitor with IC50 of 4 nM and 13 nM, respectively.; IC50 Value: 4 nM (Aurora A); 13 nM (Aurora B)[1]. MedChem Express HY-10482
      SCH 1473759 is a novel sub-nanomolar Aurora A/B inhibitor with IC50 of 4 nM and 13 nM, respectively.;IC50 Value: 4 nM (Aurora A); 13 nM (Aurora B)[1]. ;Target: Aurora Kinase;In vitro: Asynchronous cells required 24-h exposure to SCH 1473759 for maximal induction of >4 N DNA content and inhibition of cell growth. However, following taxane- or KSP inhibitor-induced mitotic arrest, less than 4-h exposure induced >4 N DNA content. This finding correlated with the ability of SCH 1473759 to accelerate exit from mitosis in response to taxane- and KSP inhibitor-induced arrest [2].;In vivo: SCH-1473759 showed efficacy and target engagement in A2780 human tumor xenograft model in mouse, and also acceptable pharmacokinetic dosing in dog, monkey and rodents, on target efficacy, as well as a safety profile in dogs[1].Protocol(Only for Reference) [1]Kinase assay:Aurora A and Aurora B kinase assays were performed in low protein binding 384-well plates. Compounds were diluted in 100% DM MedChem Express HY-10482

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.4±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.714
Molar Refractivity: 119.2±0.5 cm3
#H bond acceptors: 9
#H bond donors: 3
#Freely Rotating Bonds: 8
#Rule of 5 Violations: 0
ACD/LogP: 2.55
ACD/LogD (pH 5.5): 0.68
ACD/BCF (pH 5.5): 1.01
ACD/KOC (pH 5.5): 16.25
ACD/LogD (pH 7.4): 1.79
ACD/BCF (pH 7.4): 13.01
ACD/KOC (pH 7.4): 208.33
Polar Surface Area: 136 Å2
Polarizability: 47.3±0.5 10-24cm3
Surface Tension: 56.8±7.0 dyne/cm
Molar Volume: 303.8±7.0 cm3

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