ChemSpider 2D Image | N-(4-{[3-(2-Amino-4-pyrimidinyl)-2-pyridinyl]oxy}phenyl)-4-(4-methyl-2-thienyl)-1-phthalazinamine | C28H21N7OS

N-(4-{[3-(2-Amino-4-pyrimidinyl)-2-pyridinyl]oxy}phenyl)-4-(4-methyl-2-thienyl)-1-phthalazinamine

  • Molecular FormulaC28H21N7OS
  • Average mass503.578 Da
  • Monoisotopic mass503.152832 Da
  • ChemSpider ID25069678

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

N-(4-{[3-(2-Amino-4-pyrimidinyl)-2-pyridinyl]oxy}phenyl)-4-(4-methyl-2-thienyl)-1-phthalazinamine [ACD/IUPAC Name]
1-Phthalazinamine, N-[4-[[3-(2-amino-4-pyrimidinyl)-2-pyridinyl]oxy]phenyl]-4-(4-methyl-2-thienyl)- [ACD/Index Name]
945595-80-2 [RN]
9R2G075611
AMG 900
AMG-900
N-(4-{[3-(2-Amino-4-pyrimidinyl)-2-pyridinyl]oxy}phényl)-4-(4-méthyl-2-thiényl)-1-phtalazinamine [French] [ACD/IUPAC Name]
N-(4-{[3-(2-Amino-4-pyrimidinyl)-2-pyridinyl]oxy}phenyl)-4-(4-methyl-2-thienyl)-1-phthalazinamin [German] [ACD/IUPAC Name]
N-(4-{[3-(2-aminopyrimidin-4-yl)pyridin-2-yl]oxy}phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine
N-[4-[[3-(2-Amino-4-pyrimidinyl)-2-pyridinyl]oxy]phenyl]-4-(4-methyl-2-thienyl)-1-phthalazinamine
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM; >10-fold selective for Aurora kinases than p38?, Tyk2, JNK2, Met and Tie2. MedChem Express HY-13253
      Aurora Kinase MedChem Express HY-13253
      Cell Cycle/DNA Damage MedChem Express HY-13253
      Cell Cycle/DNA Damage; MedChem Express HY-13253

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.4±0.1 g/cm3
Boiling Point: 778.7±70.0 °C at 760 mmHg
Vapour Pressure: 0.0±2.7 mmHg at 25°C
Enthalpy of Vaporization: 113.3±3.0 kJ/mol
Flash Point: 424.7±35.7 °C
Index of Refraction: 1.739
Molar Refractivity: 147.0±0.3 cm3
#H bond acceptors: 8
#H bond donors: 3
#Freely Rotating Bonds: 6
#Rule of 5 Violations: 1
ACD/LogP: 4.64
ACD/LogD (pH 5.5): 4.57
ACD/BCF (pH 5.5): 1660.06
ACD/KOC (pH 5.5): 6610.65
ACD/LogD (pH 7.4): 4.66
ACD/BCF (pH 7.4): 2048.45
ACD/KOC (pH 7.4): 8157.28
Polar Surface Area: 140 Å2
Polarizability: 58.3±0.5 10-24cm3
Surface Tension: 71.1±3.0 dyne/cm
Molar Volume: 364.9±3.0 cm3

Click to predict properties on the Chemicalize site


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