ChemSpider 2D Image | Copanlisib | C23H28N8O4

Copanlisib

  • Molecular FormulaC23H28N8O4
  • Average mass480.520 Da
  • Monoisotopic mass480.223358 Da
  • ChemSpider ID25069683

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1032568-63-0 [RN]
2-Amino-N-{7-methoxy-8-[3-(4-morpholinyl)propoxy]-2,3-dihydroimidazo[1,2-c]chinazolin-5-yl}-5-pyrimidincarboxamid [German] [ACD/IUPAC Name]
2-Amino-N-{7-methoxy-8-[3-(4-morpholinyl)propoxy]-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl}-5-pyrimidinecarboxamide [ACD/IUPAC Name]
2-Amino-N-{7-méthoxy-8-[3-(4-morpholinyl)propoxy]-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl}-5-pyrimidinecarboxamide [French] [ACD/IUPAC Name]
2-amino-N-{7-methoxy-8-[3-(morpholin-4-yl)propoxy]-2H,3H-imidazo[1,2-c]quinazolin-5-yl}pyrimidine-5-carboxamide
5-Pyrimidinecarboxamide, 2-amino-N-[2,3-dihydro-7-methoxy-8-[3-(4-morpholinyl)propoxy]imidazo[1,2-c]quinazolin-5-yl]- [ACD/Index Name]
copanlisib [Spanish] [INN]
copanlisib [French] [INN]
Copanlisib [INN] [USAN]
copanlisibum [Latin] [INN]
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

9726 [DBID]
BAY 80-6946 [DBID]
BAY-80-6946 [DBID]
WI6V529FZ9 [DBID]
BAY80-6946 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Chemical Class:

      An imidazoquinazoline that is 2,3-dihydroimidazo[1,2-c]quinazoline substituted by (2-aminopyrimidine-5-carbonyl)amino, methoxy, and 3-(morpholin-4-yl)propoxy groups at positions 5, 7 and 8, respective ly. It is a intravenous pan-class I PI3K inhibitor used for the treatment of relapsed follicular lymphoma in patients who have received at least 2 prior systemic therapies. ChEBI CHEBI:173077

    • Bio Activity:

      BAY 80-6946(Copanlisib) is a potent and highly selective reversible PI3K inhibitor for PI3K?/? with IC50 of 0.469 nM/3.72 nM.; IC50 value: 0.469/3.72 nM(PI3K?/?) [1]; Target: PI3K?/?; in vitro: BAY 80-6946 is a phosphoinositide 3-kinase (PI3K) inhibitor with potential antineoplastic activity. MedChem Express HY-15346
      PI3K MedChem Express HY-15346
      PI3K/Akt/mTOR MedChem Express HY-15346
      PI3K/Akt/mTOR; MedChem Express HY-15346

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.5±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.722
Molar Refractivity: 125.7±0.5 cm3
#H bond acceptors: 12
#H bond donors: 3
#Freely Rotating Bonds: 8
#Rule of 5 Violations: 1
ACD/LogP: -1.00
ACD/LogD (pH 5.5): -2.26
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 1.00
ACD/LogD (pH 7.4): -0.84
ACD/BCF (pH 7.4): 1.00
ACD/KOC (pH 7.4): 4.58
Polar Surface Area: 140 Å2
Polarizability: 49.8±0.5 10-24cm3
Surface Tension: 64.0±7.0 dyne/cm
Molar Volume: 317.6±7.0 cm3

Click to predict properties on the Chemicalize site


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