ChemSpider 2D Image | LY2584702 | C21H19F4N7

LY2584702

  • Molecular FormulaC21H19F4N7
  • Average mass445.416 Da
  • Monoisotopic mass445.163818 Da
  • ChemSpider ID25069691

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1082949-67-4 [RN]
1H-Pyrazolo[3,4-d]pyrimidine, 4-[4-[4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl]-1-piperidinyl]- [ACD/Index Name]
4-(4-{4-[4-Fluor-3-(trifluormethyl)phenyl]-1-methyl-1H-imidazol-2-yl}-1-piperidinyl)-1H-pyrazolo[3,4-d]pyrimidin [German] [ACD/IUPAC Name]
4-(4-{4-[4-Fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl}-1-piperidinyl)-1H-pyrazolo[3,4-d]pyrimidine [ACD/IUPAC Name]
4-(4-{4-[4-Fluoro-3-(trifluorométhyl)phényl]-1-méthyl-1H-imidazol-2-yl}-1-pipéridinyl)-1H-pyrazolo[3,4-d]pyrimidine [French] [ACD/IUPAC Name]
4-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl}-1-{2H-pyrazolo[3,4-d]pyrimidin-4-yl}piperidine
4-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methylimidazol-2-yl}-1-{2H-pyrazolo[3,4-d]pyrimidin-4-yl}piperidine
LY2584702
LY-2584702
[1082949-67-4] [RN]
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

I4965C6W4O [DBID]
UNII:I4965C6W4O [DBID]
UNII-I4965C6W4O [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      LY-2584702 is an orally available inhibitor of p70S6K signaling; inhibits p70S6K and prevents phosphorylation of the S6 subunit of ribosomes. MedChem Express
      LY-2584702 is an orally available inhibitor of p70S6K signaling; inhibits p70S6K and prevents phosphorylation of the S6 subunit of ribosomes.; IC50 value:; Target: p70S6K inhibitor; LY-2584702 is an orally available inhibitor of p70S6K signaling, with potential antineoplastic activity. MedChem Express HY-12493
      LY-2584702 is an orally available inhibitor of p70S6K signaling; inhibits p70S6K and prevents phosphorylation of the S6 subunit of ribosomes.;IC50 value:;Target: p70S6K inhibitorLY-2584702 is an orally available inhibitor of p70S6K signaling, with potential antineoplastic activity. LY2584702 inhibits ribosomal protein S6 Kinase (p70S6K), and prevents phosphorylation of the S6 subunit of ribosomes, thereby inhibiting normal ribosomal function within tumor cells leading to a decrease in protein synthesis and in cellular proliferation. P70S6K, a serine/threonine kinase, acts downstream of PIP3 and phosphoinositide-dependent kinase-1 in the PI3 kinase pathway, is often upregulated in a variety of cancer cells, and is involved in the regulation of cell growth, proliferation, motility, and survival. MedChem Express HY-12493
      MAPK MedChem Express HY-12493
      MAPK; MedChem Express HY-12493
      Ribosomal S6 Kinase (RSK) MedChem Express HY-12493

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.5±0.1 g/cm3
Boiling Point: 665.3±55.0 °C at 760 mmHg
Vapour Pressure: 0.0±2.0 mmHg at 25°C
Enthalpy of Vaporization: 97.8±3.0 kJ/mol
Flash Point: 356.2±31.5 °C
Index of Refraction: 1.683
Molar Refractivity: 109.6±0.5 cm3
#H bond acceptors: 7
#H bond donors: 1
#Freely Rotating Bonds: 4
#Rule of 5 Violations: 0
ACD/LogP: 3.37
ACD/LogD (pH 5.5): 2.14
ACD/BCF (pH 5.5): 10.71
ACD/KOC (pH 5.5): 69.11
ACD/LogD (pH 7.4): 3.63
ACD/BCF (pH 7.4): 330.40
ACD/KOC (pH 7.4): 2132.96
Polar Surface Area: 76 Å2
Polarizability: 43.4±0.5 10-24cm3
Surface Tension: 49.4±7.0 dyne/cm
Molar Volume: 289.0±7.0 cm3

Click to predict properties on the Chemicalize site


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