ChemSpider 2D Image | Pf-04937319 | C22H20N6O4

Pf-04937319

  • Molecular FormulaC22H20N6O4
  • Average mass432.432 Da
  • Monoisotopic mass432.154602 Da
  • ChemSpider ID26328850

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1245603-92-2 [RN]
2-Pyrimidinecarboxamide, N,N-dimethyl-5-[[2-methyl-6-[[(5-methyl-2-pyrazinyl)amino]carbonyl]-4-benzofuranyl]oxy]- [ACD/Index Name]
MFCD26960571
N, N-Dimethyl-5-((2-methyl-6-((5-methylpyrazin-2-yl)carbamoyl)benzofuran-4-yl)oxy)pyrimidine-2-carboxamide
N,N-Dimethyl-5-({2-methyl-6-[(5-methyl-2-pyrazinyl)carbamoyl]-1-benzofuran-4-yl}oxy)-2-pyrimidincarboxamid [German] [ACD/IUPAC Name]
N,N-Dimethyl-5-({2-methyl-6-[(5-methyl-2-pyrazinyl)carbamoyl]-1-benzofuran-4-yl}oxy)-2-pyrimidinecarboxamide [ACD/IUPAC Name]
N,N-Diméthyl-5-({2-méthyl-6-[(5-méthyl-2-pyrazinyl)carbamoyl]-1-benzofuran-4-yl}oxy)-2-pyrimidinecarboxamide [French] [ACD/IUPAC Name]
N,N-Dimethyl-5-({2-Methyl-6-[(5-Methylpyrazin-2-Yl)carbamoyl]-1-Benzofuran-4-Yl}oxy)pyrimidine-2-Carboxamide
N,N-Dimethyl-5-[[2-methyl-6-[[(5-methyl-2-pyrazinyl)amino]carbonyl]-4-benzofuranyl]oxy]-2-pyrimidinecarboxamide
Pf-04937319
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

7E99B9ZM19 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Safety:

      Sold for research purposes under agreement from Pfizer Inc. Tocris Bioscience 6049

    • Bio Activity:

      Enzymes Tocris Bioscience 6049
      Glucokinase partial activator Tocris Bioscience 6049
      Glucokinase partial activator (EC50 = 174 nM). Acts synergistically with metformin (Cat. No. 2864) to improve glycemic control in adult with type 2 diabetes. Tocris Bioscience 6049
      Glucokinase partial activator (EC50 = 174 nM). Enhances glucose-stimulated insulin secretion in islet cell cultures and translocation of glucokinase from the nucleus to the cytoplasm in hepatocytes in vitro. Reduces post-prandial plasma glucose levels in an oral glucose tolerance test in rats. Tocris Bioscience 6049
      Hexokinases Tocris Bioscience 6049
      Kinases Tocris Bioscience 6049

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.4±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.667
Molar Refractivity: 117.8±0.3 cm3
#H bond acceptors: 10
#H bond donors: 1
#Freely Rotating Bonds: 5
#Rule of 5 Violations: 1
ACD/LogP: 1.29
ACD/LogD (pH 5.5): 1.78
ACD/BCF (pH 5.5): 13.34
ACD/KOC (pH 5.5): 222.26
ACD/LogD (pH 7.4): 1.78
ACD/BCF (pH 7.4): 13.33
ACD/KOC (pH 7.4): 222.21
Polar Surface Area: 123 Å2
Polarizability: 46.7±0.5 10-24cm3
Surface Tension: 64.9±3.0 dyne/cm
Molar Volume: 316.5±3.0 cm3

Click to predict properties on the Chemicalize site


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