ChemSpider 2D Image | AMG 837 | C26H21F3O3

AMG 837

  • Molecular FormulaC26H21F3O3
  • Average mass438.438 Da
  • Monoisotopic mass438.144287 Da
  • ChemSpider ID26612026

  • defined stereocentres - 1 of 1 defined stereocentres

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(3S)-3-(4-{[4'-(Trifluormethyl)-3-biphenylyl]methoxy}phenyl)-4-hexinsäure [German] [ACD/IUPAC Name]
(3S)-3-(4-{[4'-(Trifluoromethyl)-3-biphenylyl]methoxy}phenyl)-4-hexynoic acid [ACD/IUPAC Name]
865231-46-5 [RN]
Acide (3S)-3-(4-{[4'-(trifluorométhyl)-3-biphénylyl]méthoxy}phényl)-4-hexynoïque [French] [ACD/IUPAC Name]
AMG 837
AMG-837
Benzenepropanoic acid, β-1-propyn-1-yl-4-[[4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]methoxy]-, (βS)- [ACD/Index Name]
(3S)-3-(4-{[4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl]methoxy}phenyl)hex-4-ynoic acid
(3S)-3-(4-{[4'-(Trifluoromethyl)[1,1'-biphenyl]-3-yl]methoxy}phenyl)hex-4-ynoic acid
(3S)-3-[4-({3-[4-(trifluoromethyl)phenyl]phenyl}methoxy)phenyl]hex-4-ynoic acid
More...
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      AMG 837 is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. MedChem Express
      GPCR/G protein; MedChem Express HY-13967
      GPR40 MedChem Express HY-13967

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.3±0.1 g/cm3
Boiling Point: 565.8±50.0 °C at 760 mmHg
Vapour Pressure: 0.0±1.6 mmHg at 25°C
Enthalpy of Vaporization: 89.4±3.0 kJ/mol
Flash Point: 296.0±30.1 °C
Index of Refraction: 1.568
Molar Refractivity: 114.6±0.3 cm3
#H bond acceptors: 3
#H bond donors: 1
#Freely Rotating Bonds: 9
#Rule of 5 Violations: 1
ACD/LogP: 6.81
ACD/LogD (pH 5.5): 5.09
ACD/BCF (pH 5.5): 2099.68
ACD/KOC (pH 5.5): 3497.08
ACD/LogD (pH 7.4): 3.32
ACD/BCF (pH 7.4): 35.47
ACD/KOC (pH 7.4): 59.08
Polar Surface Area: 47 Å2
Polarizability: 45.4±0.5 10-24cm3
Surface Tension: 43.7±3.0 dyne/cm
Molar Volume: 350.5±3.0 cm3

Click to predict properties on the Chemicalize site


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