ChemSpider 2D Image | BNC-105 | C20H20O7

BNC-105

  • Molecular FormulaC20H20O7
  • Average mass372.369 Da
  • Monoisotopic mass372.120911 Da
  • ChemSpider ID26619094

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(7-Hydroxy-6-methoxy-2-methyl-1-benzofuran-3-yl)(3,4,5-trimethoxyphenyl)methanon [German] [ACD/IUPAC Name]
(7-Hydroxy-6-methoxy-2-methyl-1-benzofuran-3-yl)(3,4,5-trimethoxyphenyl)methanone [ACD/IUPAC Name]
(7-Hydroxy-6-méthoxy-2-méthyl-1-benzofuran-3-yl)(3,4,5-triméthoxyphényl)méthanone [French] [ACD/IUPAC Name]
6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)-1-benzofuran-7-ol
945771-74-4 [RN]
BNC-105
Methanone, (7-hydroxy-6-methoxy-2-methyl-3-benzofuranyl)(3,4,5-trimethoxyphenyl)- [ACD/Index Name]
Z3S2Z6H7B0
(7-hydroxy-6-methoxy-2-methyl-1-benzofuran-3-yl)-(3,4,5-trimethoxyphenyl)methanone
(7-hydroxy-6-methoxy-2-methyl-3-benzofuranyl)-(3,4,5-trimethoxyphenyl)methanone
More...
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      BNC105 is a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties. MedChem Express
      BNC105 is a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.; IC50 value: ; Target:; BNC105 exhibited excellent potency against a panel of different cancer cell lines with IC50 <1 nM for DU145, Calu-6, MDA-MB-231 etc. MedChem Express HY-16114
      BNC105 is a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.;IC50 value: ;Target:BNC105 exhibited excellent potency against a panel of different cancer cell lines with IC50 <1 nM for DU145, Calu-6, MDA-MB-231 etc. The selectivity observed for BNC105 against activated over quiescent HUVECs was also observed in human aortic arterial endothelial cells (HAAECs). BNC105 also exhibited good potency toward the cisplatin resistant cell line A2780cis. MedChem Express HY-16114
      Cell Cycle/DNA Damage MedChem Express HY-16114
      Cell Cycle/DNA Damage; MedChem Express HY-16114
      Microtubule/Tubulin MedChem Express HY-16114

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.3±0.1 g/cm3
Boiling Point: 529.3±50.0 °C at 760 mmHg
Vapour Pressure: 0.0±1.4 mmHg at 25°C
Enthalpy of Vaporization: 83.5±3.0 kJ/mol
Flash Point: 273.9±30.1 °C
Index of Refraction: 1.590
Molar Refractivity: 99.6±0.3 cm3
#H bond acceptors: 7
#H bond donors: 1
#Freely Rotating Bonds: 6
#Rule of 5 Violations: 0
ACD/LogP: 3.07
ACD/LogD (pH 5.5): 2.64
ACD/BCF (pH 5.5): 58.45
ACD/KOC (pH 5.5): 626.29
ACD/LogD (pH 7.4): 1.81
ACD/BCF (pH 7.4): 8.60
ACD/KOC (pH 7.4): 92.19
Polar Surface Area: 87 Å2
Polarizability: 39.5±0.5 10-24cm3
Surface Tension: 44.9±3.0 dyne/cm
Molar Volume: 295.2±3.0 cm3

Click to predict properties on the Chemicalize site


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