ChemSpider 2D Image | N-{4-[2-(2-Propyl-4-pyridinyl)-1,3-thiazol-4-yl]phenyl}methanesulfonamide | C18H19N3O2S2

N-{4-[2-(2-Propyl-4-pyridinyl)-1,3-thiazol-4-yl]phenyl}methanesulfonamide

  • Molecular FormulaC18H19N3O2S2
  • Average mass373.492 Da
  • Monoisotopic mass373.091858 Da
  • ChemSpider ID26620887

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1046045-61-7 [RN]
Methanesulfonamide, N-[4-[2-(2-propyl-4-pyridinyl)-4-thiazolyl]phenyl]- [ACD/Index Name]
N-{4-[2-(2-Propyl-4-pyridinyl)-1,3-thiazol-4-yl]phenyl}methanesulfonamide [ACD/IUPAC Name]
N-{4-[2-(2-Propyl-4-pyridinyl)-1,3-thiazol-4-yl]phényl}méthanesulfonamide [French] [ACD/IUPAC Name]
N-{4-[2-(2-Propyl-4-pyridinyl)-1,3-thiazol-4-yl]phenyl}methansulfonamid [German] [ACD/IUPAC Name]
N-{4-[2-(2-propylpyridin-4-yl)-1,3-thiazol-4-yl]phenyl}methanesulfonamide
FGH10019
FGH-10019
N-(4-(2-(2-Propylpyridin-4-yl)thiazol-4-yl)phenyl)methanesulfonamide
N-?[4-?[2-?(2-?propyl-?4-?pyridinyl)?-?4-?thiazolyl]?phenyl]?-Methanesulfonamide
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  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      FGH10019 is a novel sterol regulatory element-binding protein (SREBP) inhibitor with IC50 of 1 uM; 5?10 times lower than the IC50 of fatostatin (~10 ?M).; IC50 value: 1 uM [1]; Target: SREBP inhibitor; FGH10019 is a methanesulfonamide derivative of fatostatin, exhibited the highest activity in a cell-based assay, and exhibited better in vitro and in vivo physicochemical properties than fatostatin or the other derivatives that were synthesized and evaluated. MedChem Express HY-16207
      Others MedChem Express HY-16207

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.3±0.1 g/cm3
Boiling Point: 578.4±60.0 °C at 760 mmHg
Vapour Pressure: 0.0±1.6 mmHg at 25°C
Enthalpy of Vaporization: 86.6±3.0 kJ/mol
Flash Point: 303.6±32.9 °C
Index of Refraction: 1.624
Molar Refractivity: 100.9±0.4 cm3
#H bond acceptors: 5
#H bond donors: 1
#Freely Rotating Bonds: 6
#Rule of 5 Violations: 0
ACD/LogP: 3.97
ACD/LogD (pH 5.5): 3.31
ACD/BCF (pH 5.5): 191.01
ACD/KOC (pH 5.5): 1475.04
ACD/LogD (pH 7.4): 2.68
ACD/BCF (pH 7.4): 45.18
ACD/KOC (pH 7.4): 348.88
Polar Surface Area: 109 Å2
Polarizability: 40.0±0.5 10-24cm3
Surface Tension: 56.6±3.0 dyne/cm
Molar Volume: 285.7±3.0 cm3

Click to predict properties on the Chemicalize site


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