ChemSpider 2D Image | CP466722 | C17H15N7O2

CP466722

  • Molecular FormulaC17H15N7O2
  • Average mass349.347 Da
  • Monoisotopic mass349.128723 Da
  • ChemSpider ID27445283

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1-(6,7-Dimethoxy-4-chinazolinyl)-3-(2-pyridinyl)-1H-1,2,4-triazol-5-amin [German] [ACD/IUPAC Name]
1-(6,7-Dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-1H-1,2,4-triazol-5-amine [ACD/IUPAC Name]
1-(6,7-Diméthoxy-4-quinazolinyl)-3-(2-pyridinyl)-1H-1,2,4-triazol-5-amine [French] [ACD/IUPAC Name]
1-(6,7-dimethoxyquinazolin-4-yl)-3-(pyridin-2-yl)-1H-1,2,4-triazol-5-amine
1080622-86-1 [RN]
1H-1,2,4-Triazol-5-amine, 1-(6,7-dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)- [ACD/Index Name]
2-(6,7-dimethoxy-4-quinazolinyl)-5-(2-pyridinyl)-1,2,4-triazol-3-amine
2-(6,7-dimethoxyquinazolin-4-yl)-5-(pyridin-2-yl)-1,2,4-triazol-3-amine
CP 466,722
CP466722
More...
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      ATM MedChem Express HY-11002
      Cell Cycle/DNA Damage MedChem Express HY-11002
      Cell Cycle/DNA Damage; PI3K/Akt/mTOR ; MedChem Express HY-11002
      CP-466722 is rapidly reversible potential ATM kinase inhibitor. MedChem Express
      CP-466722 is rapidly reversible potential ATM kinase inhibitor.; IC50 Value:; Target: ATM; CP-466722 is non-toxic and does not inhibit PI3K or PI3K-like protein kinase family members in cells. MedChem Express HY-11002
      CP-466722 is rapidly reversible potential ATM kinase inhibitor.;IC50 Value:;Target: ATMCP-466722 is non-toxic and does not inhibit PI3K or PI3K-like protein kinase family members in cells. CP-466722 inhibited cellular ATM-dependent phosphorylation events and disruption of ATM function resulted in characteristic cell cycle checkpoint defects. Inhibition of cellular ATM kinase activity was rapidly and completely reversed by removing CP-466722. Interestingly, clonogenic survival assays demonstrated that transient inhibition of ATM is sufficient to sensitize cells to ionizing radiation and suggests that therapeutic radiosensitization may only require ATM inhibition for short periods of time. The ability of CP-466722 to rapidly and reversibly regulate ATM activity provides a new tool to ask questions about ATM function that could not easily be addressed using genetic models or RNA interference technologies. MedChem Express HY-11002

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.5±0.1 g/cm3
Boiling Point: 642.3±65.0 °C at 760 mmHg
Vapour Pressure: 0.0±1.9 mmHg at 25°C
Enthalpy of Vaporization: 94.8±3.0 kJ/mol
Flash Point: 342.2±34.3 °C
Index of Refraction: 1.737
Molar Refractivity: 94.2±0.5 cm3
#H bond acceptors: 9
#H bond donors: 2
#Freely Rotating Bonds: 4
#Rule of 5 Violations: 0
ACD/LogP: 0.83
ACD/LogD (pH 5.5): 1.07
ACD/BCF (pH 5.5): 3.86
ACD/KOC (pH 5.5): 91.45
ACD/LogD (pH 7.4): 1.07
ACD/BCF (pH 7.4): 3.86
ACD/KOC (pH 7.4): 91.45
Polar Surface Area: 114 Å2
Polarizability: 37.4±0.5 10-24cm3
Surface Tension: 60.8±7.0 dyne/cm
Molar Volume: 234.5±7.0 cm3

Click to predict properties on the Chemicalize site


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