ChemSpider 2D Image | HSP-990 | C20H18FN5O2

HSP-990

  • Molecular FormulaC20H18FN5O2
  • Average mass379.388 Da
  • Monoisotopic mass379.144440 Da
  • ChemSpider ID28189060

  • defined stereocentres - 1 of 1 defined stereocentres

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(7R)-2-Amino-7-[4-fluor-2-(6-methoxy-2-pyridinyl)phenyl]-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-on [German] [ACD/IUPAC Name]
(7R)-2-Amino-7-[4-fluoro-2-(6-methoxy-2-pyridinyl)phenyl]-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one [ACD/IUPAC Name]
(7R)-2-Amino-7-[4-fluoro-2-(6-méthoxy-2-pyridinyl)phényl]-4-méthyl-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one [French] [ACD/IUPAC Name]
(7R)-2-amino-7-[4-fluoro-2-(6-methoxypyridin-2-yl)phenyl]-4-methyl-5H,6H,7H,8H-pyrido[4,3-d]pyrimidin-5-one
(7R)-2-amino-7-[4-fluoro-2-(6-methoxypyridin-2-yl)phenyl]-4-methyl-6H,7H,8H-pyrido[4,3-d]pyrimidin-5-one
934343-74-5 [RN]
E0WBA7B62L
HSP-990
Pyrido[4,3-d]pyrimidin-5(6H)-one, 2-amino-7-[4-fluoro-2-(6-methoxy-2-pyridinyl)phenyl]-7,8-dihydro-4-methyl-, (7R)- [ACD/Index Name]
(7R)-2-amino-7-[4-fluoro-2-(6-methoxy-2-pyridinyl)phenyl]-7,8-dihydro-4-methyl-pyrido[4,3-d]pyrimidin-5(6H)-one
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

990 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      Cell Cycle/DNA Damage MedChem Express HY-15190
      Cell Cycle/DNA Damage; Metabolism/Protease; MedChem Express HY-15190
      HSP MedChem Express HY-15190
      NVP-HSP990(HSP990) is an orally bioavailable inhibitor of Hsp90(IC50=13 nM; Hsp90?) with potential antineoplastic activity.; IC50 value: 13 nM(Hsp90?) [1]; Target: Hsp90 inhibitor; in vitro: NVP-HSP990 triggered apoptosis in a panel of human multiple myeloma cells, induced cell-cycle arrest, PARP cleavage, downregulation of client proteins, the inability to reactivate phospho-STAT3 following exogenous IL-6 stimulation, and it synergized with azacytidine and bortezomib in cell lines and primary multiple myeloma samples [2]. MedChem Express HY-15190

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.3±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.627
Molar Refractivity: 100.9±0.3 cm3
#H bond acceptors: 7
#H bond donors: 3
#Freely Rotating Bonds: 3
#Rule of 5 Violations: 0
ACD/LogP: 1.44
ACD/LogD (pH 5.5): 1.95
ACD/BCF (pH 5.5): 17.98
ACD/KOC (pH 5.5): 275.08
ACD/LogD (pH 7.4): 1.96
ACD/BCF (pH 7.4): 18.03
ACD/KOC (pH 7.4): 275.79
Polar Surface Area: 103 Å2
Polarizability: 40.0±0.5 10-24cm3
Surface Tension: 58.9±3.0 dyne/cm
Molar Volume: 284.7±3.0 cm3

Click to predict properties on the Chemicalize site


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