ChemSpider 2D Image | SGI-1776 | C20H22F3N5O

SGI-1776

  • Molecular FormulaC20H22F3N5O
  • Average mass405.417 Da
  • Monoisotopic mass405.177643 Da
  • ChemSpider ID28497930

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1025065-69-3 [RN]
72AUA0603W
Imidazo[1,2-b]pyridazin-6-amine, N-[(1-methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]- [ACD/Index Name]
N-[(1-Methyl-4-piperidinyl)methyl]-3-[3-(trifluormethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amin [German] [ACD/IUPAC Name]
N-[(1-Methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amine [ACD/IUPAC Name]
N-[(1-Méthyl-4-pipéridinyl)méthyl]-3-[3-(trifluorométhoxy)phényl]imidazo[1,2-b]pyridazin-6-amine [French] [ACD/IUPAC Name]
SGI-1776
??N-[(1-methylpiperidin-4-yl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amine
[1025065-69-3] [RN]
MFCD16659064 [MDL number]
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

PubChem Substance ID 329825761 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Target Organs:

      Pim inhibitor; FLT3 inhibitor TargetMol T3078

    • Bio Activity:

      JAK/STAT Signaling MedChem Express HY-13287
      JAK/STAT Signaling TargetMol T3078
      JAK/STAT Signaling; MedChem Express HY-13287
      Pim MedChem Express HY-13287
      Pim1; FLT3; Pim3;Pim2 TargetMol T3078
      SGI-1776 is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM; 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. MedChem Express HY-13287
      SGI-1776 is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM; 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. ;IC50 value: 7 nM [1];Target: Pim1;In vitro: In addition to Pim, SGI-1776 also potently targets FLT3 (IC50 = 44nM). Treatment of AML cells with SGI-1776 results in a concentration-dependent induction of apoptosis. Importantly, SGI-1776 is also cytotoxic in AML primary cells, irrespective of FLT3 mutation status and results in Mcl-1 protein decline [1]. Treatment of CLL cells with SGI-1776 results in a concentration-dependent induction of apoptosis. SGI-1776 induces apoptosis in CLL and that the mechanism involves Mcl-1 reduction. Apoptosis induction coupled with the inhibition of RNA synthesis is observed in CLL cells treated with SGI-1776 [2]. SGI-1776 exhibites cytotoxic activity in vitro with a median relative IC50 of 3.1 mM. SGI-1776 induces tumor growth inhibition meeting criteria for intermediate EFS T/C activity in 1 of 39 e MedChem Express HY-13287

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.4±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.613
Molar Refractivity: 102.9±0.5 cm3
#H bond acceptors: 6
#H bond donors: 1
#Freely Rotating Bonds: 6
#Rule of 5 Violations: 0
ACD/LogP: 3.36
ACD/LogD (pH 5.5): 0.01
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 1.00
ACD/LogD (pH 7.4): 1.28
ACD/BCF (pH 7.4): 2.08
ACD/KOC (pH 7.4): 18.32
Polar Surface Area: 55 Å2
Polarizability: 40.8±0.5 10-24cm3
Surface Tension: 44.1±7.0 dyne/cm
Molar Volume: 295.7±7.0 cm3

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