ChemSpider 2D Image | 5-[2-{[4-(Methylsulfonyl)-1-piperazinyl]methyl}-8-(4-morpholinyl)imidazo[1,2-a]pyrazin-6-yl]-2-pyrimidinamine | C20H27N9O3S

5-[2-{[4-(Methylsulfonyl)-1-piperazinyl]methyl}-8-(4-morpholinyl)imidazo[1,2-a]pyrazin-6-yl]-2-pyrimidinamine

  • Molecular FormulaC20H27N9O3S
  • Average mass473.552 Da
  • Monoisotopic mass473.195770 Da
  • ChemSpider ID28515553

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1252594-99-2 [RN]
2-Pyrimidinamine, 5-[2-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-8-(4-morpholinyl)imidazo[1,2-a]pyrazin-6-yl]- [ACD/Index Name]
5-[2-{[4-(Methylsulfonyl)-1-piperazinyl]methyl}-8-(4-morpholinyl)imidazo[1,2-a]pyrazin-6-yl]-2-pyrimidinamin [German] [ACD/IUPAC Name]
5-[2-{[4-(Methylsulfonyl)-1-piperazinyl]methyl}-8-(4-morpholinyl)imidazo[1,2-a]pyrazin-6-yl]-2-pyrimidinamine [ACD/IUPAC Name]
5-[2-{[4-(Méthylsulfonyl)-1-pipérazinyl]méthyl}-8-(4-morpholinyl)imidazo[1,2-a]pyrazin-6-yl]-2-pyrimidinamine [French] [ACD/IUPAC Name]
5-{2-[(4-methanesulfonylpiperazin-1-yl)methyl]-8-(morpholin-4-yl)imidazo[1,2-a]pyrazin-6-yl}pyrimidin-2-amine
5-[2-[(4-methylsulfonylpiperazin-1-yl)methyl]-8-morpholin-4-ylimidazo[1,2-a]pyrazin-6-yl]pyrimidin-2-amine
ETP 46321
ETP 46321;ETP46321
ETP46321
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  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      ETP-46321 is a potent and orally bioavailable PI3K ?/? inhibitor with IC50 of 2.3/14.2 nM for p110?/p110?; exhibits potency on mutated p110?(IC50=1.77-2.33 nM, p110a E542K; E545K; H1047R).; IC50 value: 2.3/14.2 nM(p110?/p110?); Target: PI3K ?/? inhibitor; ETP-46321, has; been pro?led and shown to be a potent PI3K a and d inhibitor,; highly selective versus mTOR and 288 representative kinases. MedChem Express HY-12340
      PI3K MedChem Express HY-12340
      PI3K/Akt/mTOR MedChem Express HY-12340
      PI3K/Akt/mTOR; MedChem Express HY-12340

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.6±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.768
Molar Refractivity: 122.9±0.5 cm3
#H bond acceptors: 12
#H bond donors: 2
#Freely Rotating Bonds: 5
#Rule of 5 Violations: 1
ACD/LogP: -1.02
ACD/LogD (pH 5.5): -0.89
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 5.71
ACD/LogD (pH 7.4): -0.60
ACD/BCF (pH 7.4): 1.00
ACD/KOC (pH 7.4): 11.16
Polar Surface Area: 143 Å2
Polarizability: 48.7±0.5 10-24cm3
Surface Tension: 73.6±7.0 dyne/cm
Molar Volume: 296.4±7.0 cm3

Click to predict properties on the Chemicalize site


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