ChemSpider 2D Image | NG-25 | C29H30F3N5O2

NG-25

  • Molecular FormulaC29H30F3N5O2
  • Average mass537.576 Da
  • Monoisotopic mass537.235168 Da
  • ChemSpider ID28637815

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1315355-93-1 [RN]
Benzamide, N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)- [ACD/Index Name]
MFCD19443255
N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-benzamide trihydrochloride
N-{4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluormethyl)phenyl}-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamid [German] [ACD/IUPAC Name]
N-{4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl}-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide [ACD/IUPAC Name]
N-{4-[(4-Éthyl-1-pipérazinyl)méthyl]-3-(trifluorométhyl)phényl}-4-méthyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide [French] [ACD/IUPAC Name]
N-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-4-methyl-3-{1H-pyrrolo[2,3-b]pyridin-4-yloxy}benzamide
NG-25
[1315355-93-1] [RN]
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

CCRIS 4693 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Safety:

      Sold under license from Dana-Farber Cancer Institute. Tocris Bioscience 5429

    • Bio Activity:

      Enzymes Tocris Bioscience 5429
      Kinases Tocris Bioscience 5429
      NF-KB MedChem Express HY-15434
      NF-KB; MedChem Express HY-15434
      NG25, a TAK1 inhibitor, inhibited the activation of IKK by TLR7 and TLR9 agonists and prevented the secretion of type 1 IFNs induced by these ligands in Gen2.2 cells. MedChem Express
      NG25, a TAK1 inhibitor, inhibited the activation of IKK by TLR7 and TLR9 agonists and prevented the secretion of type 1 IFNs induced by these ligands in Gen2.2 cells.; IC50 value:; Target: TAK1 MedChem Express HY-15434
      NG25, a TAK1 inhibitor, inhibited the activation of IKK by TLR7 and TLR9 agonists and prevented the secretion of type 1 IFNs induced by these ligands in Gen2.2 cells.;IC50 value:;Target: TAK1 MedChem Express HY-15434
      Other Kinases Tocris Bioscience 5429
      TAK1 MedChem Express HY-15434
      TGF-?-activated kinase (TAK1) inhibitor Tocris Bioscience 5429
      TGF-?-activated kinase (TAK1) inhibitor (IC50 = 149 nM). Also inhibits LYN, MAP4K2 and Abl kinase activity (IC50 values are 12.9, 21.7 and 75.2 nM, respectively). Suppresses CpG A and CpG B-stimulated secretion of IFN-? and TLR7/8 agonist CL097-stimulated secretion of IFN-? in Gen 2.2 leukemia cells in vitro. Tocris Bioscience 5429
      TGF-?-activated kinase (TAK1) inhibitor (IC50 = 149 nM). Also inhibits LYN, MAP4K2 and Abl kinase activity (IC50 values are 12.9, 21.7 and 75.2 nM, respectively). Suppresses CpG A and CpG B-stimulated secretion of IFN-? and TLR7/8 agonist CL097-stimulated secretion of IFN-? in Gen 2.2 leukemia cells in vitro. Tocris Bioscience 5429
      TGF-beta-activated kinase (TAK1) inhibitor Tocris Bioscience 5429
      TGF-beta-activated kinase (TAK1) inhibitor (IC50 = 149 nM). Also inhibits LYN, MAP4K2 and Abl kinase activity (IC50 values are 12.9, 21.7 and 75.2 nM, respectively). Suppresses CpG A and CpG B-stimulated secretion of IFN-alpha and TLR7/8 agonist CL097-stimulated secretion of IFN-beta in Gen 2.2 leukemia cells in vitro. Tocris Bioscience 5429

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.3±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.628
Molar Refractivity: 145.3±0.3 cm3
#H bond acceptors: 7
#H bond donors: 2
#Freely Rotating Bonds: 8
#Rule of 5 Violations: 2
ACD/LogP: 5.87
ACD/LogD (pH 5.5): 1.99
ACD/BCF (pH 5.5): 3.92
ACD/KOC (pH 5.5): 14.30
ACD/LogD (pH 7.4): 4.30
ACD/BCF (pH 7.4): 819.68
ACD/KOC (pH 7.4): 2989.46
Polar Surface Area: 73 Å2
Polarizability: 57.6±0.5 10-24cm3
Surface Tension: 53.5±3.0 dyne/cm
Molar Volume: 409.4±3.0 cm3

Click to predict properties on the Chemicalize site


Advertisement