ChemSpider 2D Image | TAK-593 | C23H23N7O3

TAK-593

  • Molecular FormulaC23H23N7O3
  • Average mass445.474 Da
  • Monoisotopic mass445.186249 Da
  • ChemSpider ID28669643

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1005780-62-0 [RN]
1H-Pyrazole-5-carboxamide, N-[5-[[2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl]oxy]-2-methylphenyl]-1,3-dimethyl- [ACD/Index Name]
H3I42X8XX7
N-[5-({2-[(Cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazol-5-carboxamid [German] [ACD/IUPAC Name]
N-[5-({2-[(Cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide [ACD/IUPAC Name]
N-[5-({2-[(Cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-méthylphényl]-1,3-diméthyl-1H-pyrazole-5-carboxamide [French] [ACD/IUPAC Name]
N-[5-({2-cyclopropaneamidoimidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide
N-[5-({2-cyclopropaneamidoimidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-2,5-dimethylpyrazole-3-carboxamide
TAK-593
N-[5-[[2-[(cyclopropyl-oxomethyl)amino]-6-imidazo[2,1-f]pyridazinyl]oxy]-2-methylphenyl]-2,5-dimethyl-3-pyrazolecarboxamide
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  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      PDGFR MedChem Express HY-15506
      PDGFR VEGFR MedChem Express HY-15506
      Protein Tyrosine Kinase/RTK MedChem Express HY-15506
      Protein Tyrosine Kinase/RTK; MedChem Express HY-15506
      TAK-593 is a potent and selective dual VEGFR/PDGFR inhibitor with IC50s of 3.2/0.95/1.1 nM(VEGFR1/2/3) and 4.3/1/13 nM(PDGFR?/PDGFR? V561D/PDGFR?); with an IC50 >1 ?M when tested against more than 200 protein and lipid kinases.; IC50 value: 3.2/0.95/1.1 nM(VEGFR1/2/3); 4.3/1/13 nM(PDGFR?/PDGFR? V561D/PDGFR?) [1]; Target: VEGFR/PDGFR; in vitro: TAK-593, a novel imidazo[1,2-b]pyridazine derivative, potently inhibits tyrosine kinases from the VEGFR and PDGFR families. MedChem Express HY-15506

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.5±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.733
Molar Refractivity: 121.5±0.5 cm3
#H bond acceptors: 10
#H bond donors: 2
#Freely Rotating Bonds: 6
#Rule of 5 Violations: 1
ACD/LogP: 1.52
ACD/LogD (pH 5.5): 1.86
ACD/BCF (pH 5.5): 15.19
ACD/KOC (pH 5.5): 240.94
ACD/LogD (pH 7.4): 1.88
ACD/BCF (pH 7.4): 15.71
ACD/KOC (pH 7.4): 249.22
Polar Surface Area: 115 Å2
Polarizability: 48.2±0.5 10-24cm3
Surface Tension: 59.7±7.0 dyne/cm
Molar Volume: 303.5±7.0 cm3

Click to predict properties on the Chemicalize site


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