ChemSpider 2D Image | Fimepinostat | C23H24N8O4S

Fimepinostat

  • Molecular FormulaC23H24N8O4S
  • Average mass508.553 Da
  • Monoisotopic mass508.164124 Da
  • ChemSpider ID29314960

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1339928-25-4 [RN]
5-Pyrimidinecarboxamide, N-hydroxy-2-[[[2-(6-methoxy-3-pyridinyl)-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]methylamino]- [ACD/Index Name]
fimepinostat [Spanish] [INN]
Fimepinostat [INN]
fimépinostat [French] [INN]
fimepinostatum [Latin] [INN]
N-hydroxy-2-({[2-(6-methoxypyridin-3-yl)-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl}(methyl)amino)pyrimidine-5-carboxamide
N-Hydroxy-2-[{[2-(6-methoxy-3-pyridinyl)-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl}(methyl)amino]-5-pyrimidincarboxamid [German] [ACD/IUPAC Name]
N-Hydroxy-2-[{[2-(6-methoxy-3-pyridinyl)-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl}(methyl)amino]-5-pyrimidinecarboxamide [ACD/IUPAC Name]
N-Hydroxy-2-[{[2-(6-méthoxy-3-pyridinyl)-4-(4-morpholinyl)thiéno[3,2-d]pyrimidin-6-yl]méthyl}(méthyl)amino]-5-pyrimidinecarboxamide [French] [ACD/IUPAC Name]
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

3S9RX35S5X [DBID]
CUDC-907 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Target Organs:

      HDAC inhibitor TargetMol T2078

    • Bio Activity:

      Cell Cycle/DNA Damage MedChem Express HY-13522
      Cell Cycle/DNA Damage; PI3K/Akt/mTOR ; MedChem Express HY-13522
      Chromatin/Epigenetic TargetMol T2078
      CUDC-907 potently inhibits class I PI3Ks as well as classes I and II HDAC enzymes.; IC50 Value: 1.7/5.0/1.8/2.8 nM (HDAC1/2/3/10); 19/54/39 nM (PI3K?/?/?) [1]; in vitro: CUDC-907 induced the accumulation of acetylated histone H3, tubulin, and p53, as well as p21 expression in a dose-dependent manner (Supplementary Figs. MedChem Express HY-13522
      HDAC MedChem Express HY-13522
      HDAC PI3K MedChem Express HY-13522
      HDAC1/2/3/10;PI3K??/??/?? TargetMol T2078

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.4±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.696
Molar Refractivity: 135.3±0.3 cm3
#H bond acceptors: 12
#H bond donors: 2
#Freely Rotating Bonds: 7
#Rule of 5 Violations: 2
ACD/LogP: 2.39
ACD/LogD (pH 5.5): 1.54
ACD/BCF (pH 5.5): 8.61
ACD/KOC (pH 5.5): 160.94
ACD/LogD (pH 7.4): 1.26
ACD/BCF (pH 7.4): 4.58
ACD/KOC (pH 7.4): 85.54
Polar Surface Area: 167 Å2
Polarizability: 53.7±0.5 10-24cm3
Surface Tension: 78.3±3.0 dyne/cm
Molar Volume: 351.8±3.0 cm3

Click to predict properties on the Chemicalize site


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