ChemSpider 2D Image | CCG-203971 | C23H21ClN2O3

CCG-203971

  • Molecular FormulaC23H21ClN2O3
  • Average mass408.877 Da
  • Monoisotopic mass408.124084 Da
  • ChemSpider ID30813774

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1443437-74-8 [RN]
3-Piperidinecarboxamide, N-(4-chlorophenyl)-1-[3-(2-furanyl)benzoyl]- [ACD/Index Name]
CCG-203971
MFCD28166491
N-(4-chlorophenyl)-1-[3-(2-furanyl)benzoyl]-3-piperidinecarboxamide
N-(4-Chlorophenyl)-1-[3-(2-furyl)benzoyl]-3-piperidinecarboxamide [ACD/IUPAC Name]
N-(4-Chlorophényl)-1-[3-(2-furyl)benzoyl]-3-pipéridinecarboxamide [French] [ACD/IUPAC Name]
N-(4-chlorophenyl)-1-[3-(furan-2-yl)benzoyl]piperidine-3-carboxamide
N-(4-Chlorphenyl)-1-[3-(2-furyl)benzoyl]-3-piperidincarboxamid [German] [ACD/IUPAC Name]
[1443437-74-8] [RN]
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

CCRIS 4693 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      Antifibrotic agent; inhibits fibrosis by targeting the MRTF/SRF gene transcription pathway. Selectively inhibits proliferation of SSc-derived dermal fibroblasts but not that of normal fibroblasts. Inh ibits expression of CTGF, ?-SMA, and COL1A2 in SSc fibroblasts as well as in LPA and in TGF?-stimulated fibroblasts. Prevents bleomycin-induced skin thickening and collagen deposition in vivo. Also su ppresses PC-3 cell migration in scratch wound assays (IC50 = 4.2 ?M). Tocris Bioscience 5277
      Antifibrotic agent; inhibits fibrosis by targeting the MRTF/SRF gene transcription pathway. Selectively inhibits proliferation of SSc-derived dermal fibroblasts but not that of normal fibroblasts. Inhibits expression of CTGF, ?-SMA, and COL1A2 in SSc fibroblasts as well as in LPA and in TGF?-stimulated fibroblasts. Prevents bleomycin-induced skin thickening and collagen deposition in vivo. Also suppresses PC-3 cell migration in scratch wound assays (IC50 = 4.2 ?M). Tocris Bioscience 5277
      Antifibrotic agent; inhibits fibrosis by targeting the MRTF/SRF gene transcription pathway. Selectively inhibits proliferation of SSc-derived dermal fibroblasts but not that of normal fibroblasts. Inhibits expression of CTGF, alpha-SMA, and COL1A2 in SSc fibroblasts as well as in LPA and in TGFbeta-stimulated fibroblasts. Prevents bleomycin-induced skin thickening and collagen deposition in vivo. Also suppresses PC-3 cell migration in scratch wound assays (IC50 = 4.2 muM). Tocris Bioscience 5277
      Cell Biology Tocris Bioscience 5277
      Inhibits the MRTF/SRF gene transcription pathway; antifibrotic agent Tocris Bioscience 5277
      Other Transcription Factors Tocris Bioscience 5277
      Signal Transduction Tocris Bioscience 5277
      Transcription Factors Tocris Bioscience 5277

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.3±0.1 g/cm3
Boiling Point: 656.0±55.0 °C at 760 mmHg
Vapour Pressure: 0.0±2.0 mmHg at 25°C
Enthalpy of Vaporization: 96.6±3.0 kJ/mol
Flash Point: 350.5±31.5 °C
Index of Refraction: 1.633
Molar Refractivity: 111.8±0.3 cm3
#H bond acceptors: 5
#H bond donors: 1
#Freely Rotating Bonds: 4
#Rule of 5 Violations: 0
ACD/LogP: 3.76
ACD/LogD (pH 5.5): 4.23
ACD/BCF (pH 5.5): 962.53
ACD/KOC (pH 5.5): 4754.77
ACD/LogD (pH 7.4): 4.23
ACD/BCF (pH 7.4): 962.54
ACD/KOC (pH 7.4): 4754.78
Polar Surface Area: 63 Å2
Polarizability: 44.3±0.5 10-24cm3
Surface Tension: 55.8±3.0 dyne/cm
Molar Volume: 313.2±3.0 cm3

Click to predict properties on the Chemicalize site


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