ChemSpider 2D Image | NVP-TNKS656 | C27H34N4O5

NVP-TNKS656

  • Molecular FormulaC27H34N4O5
  • Average mass494.583 Da
  • Monoisotopic mass494.252930 Da
  • ChemSpider ID30819493

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1419949-20-4 [RN]
1-Piperidineacetamide, N-(cyclopropylmethyl)-4-(4-methoxybenzoyl)-N-[(3,5,7,8-tetrahydro-4-oxo-4H-pyrano[4,3-d]pyrimidin-2-yl)methyl]- [ACD/Index Name]
N-(Cyclopropylmethyl)-2-[4-(4-methoxybenzoyl)-1-piperidinyl]-N-[(4-oxo-1,5,7,8-tetrahydro-4H-pyrano[4,3-d]pyrimidin-2-yl)methyl]acetamid [German] [ACD/IUPAC Name]
N-(Cyclopropylmethyl)-2-[4-(4-methoxybenzoyl)-1-piperidinyl]-N-[(4-oxo-1,5,7,8-tetrahydro-4H-pyrano[4,3-d]pyrimidin-2-yl)methyl]acetamide [ACD/IUPAC Name]
N-(Cyclopropylméthyl)-2-[4-(4-méthoxybenzoyl)-1-pipéridinyl]-N-[(4-oxo-1,5,7,8-tétrahydro-4H-pyrano[4,3-d]pyrimidin-2-yl)méthyl]acétamide [French] [ACD/IUPAC Name]
N-(cyclopropylmethyl)-2-[4-(4-methoxybenzoyl)piperidin-1-yl]-N-({4-oxo-1H,4H,5H,7H,8H-pyrano[4,3-d]pyrimidin-2-yl}methyl)acetamide
N-(cyclopropylmethyl)-2-[4-(4-methoxybenzoyl)piperidin-1-yl]-N-({4-oxo-1H,5H,7H,8H-pyrano[4,3-d]pyrimidin-2-yl}methyl)acetamide
NVP-TNKS656
MFCD28167762
N-(cyclopropylmethyl)-2-(4-(4-methoxybenzoyl)piperidin-1-yl)-N-((4-oxo-3,5,7,8-tetrahydro-4H-pyrano[4,3-d]pyrimidin-2-yl)methyl)acetamide
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

PubChem Substance ID 329825761 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      Cell Cycle/DNA Damage MedChem Express HY-13990
      Cell Cycle/DNA Damage; MedChem Express HY-13990
      NVP-TNKS656(TNKS-656) is a highly potent, selective, and orally active TNKS2 inhibitor with IC50 of 6 nM; MedChem Express http://www.medchemexpress.com/CCG-1423.html
      NVP-TNKS656(TNKS-656) is a highly potent, selective, and orally active TNKS2 inhibitor with IC50 of 6 nM; > 300 fold selectivity against PARP1 and PARP2.; IC50 value: 6 nM [1]; Target: TNKS2; NVP-TNKS656 was identified as an orally active antagonist of Wnt pathway activity in the MMTV-Wnt1 mouse xenograft model. MedChem Express HY-13990
      NVP-TNKS656(TNKS-656) is a highly potent, selective, and orally active TNKS2 inhibitor with IC50 of 6 nM; > 300 fold selectivity against PARP1 and PARP2.;IC50 value: 6 nM [1];Target: TNKS2NVP-TNKS656 was identified as an orally active antagonist of Wnt pathway activity in the MMTV-Wnt1 mouse xenograft model. With an enthalpy-driven thermodynamic signature of binding, highly favorable physicochemical properties, and high lipophilic efficiency. MedChem Express HY-13990
      PARP MedChem Express HY-13990

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.4±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.665
Molar Refractivity: 133.4±0.5 cm3
#H bond acceptors: 9
#H bond donors: 1
#Freely Rotating Bonds: 9
#Rule of 5 Violations: 0
ACD/LogP: 2.39
ACD/LogD (pH 5.5): 0.72
ACD/BCF (pH 5.5): 1.30
ACD/KOC (pH 5.5): 24.04
ACD/LogD (pH 7.4): 1.53
ACD/BCF (pH 7.4): 8.48
ACD/KOC (pH 7.4): 157.07
Polar Surface Area: 101 Å2
Polarizability: 52.9±0.5 10-24cm3
Surface Tension: 55.1±7.0 dyne/cm
Molar Volume: 359.1±7.0 cm3

Click to predict properties on the Chemicalize site


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