ChemSpider 2D Image | YH239-EE | C25H27Cl2N3O4

YH239-EE

  • Molecular FormulaC25H27Cl2N3O4
  • Average mass504.406 Da
  • Monoisotopic mass503.137848 Da
  • ChemSpider ID31042602

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1364488-67-4 [RN]
1H-Indole-2-carboxylic acid, 6-chloro-3-[1-[[(4-chlorophenyl)methyl]formylamino]-2-[(1,1-dimethylethyl)amino]-2-oxoethyl]-, ethyl ester [ACD/Index Name]
6-Chloro-3-{1-[(4-chlorobenzyl)(formyl)amino]-2-[(2-méthyl-2-propanyl)amino]-2-oxoéthyl}-1H-indole-2-carboxylate d'éthyle [French] [ACD/IUPAC Name]
ETHYL 3-[(TERT-BUTYLCARBAMOYL)({N-[(4-CHLOROPHENYL)METHYL]FORMAMIDO})METHYL]-6-CHLORO-1H-INDOLE-2-CARBOXYLATE
Ethyl 6-chloro-3-{1-[(4-chlorobenzyl)(formyl)amino]-2-[(2-methyl-2-propanyl)amino]-2-oxoethyl}-1H-indole-2-carboxylate [ACD/IUPAC Name]
Ethyl-6-chlor-3-{1-[(4-chlorbenzyl)(formyl)amino]-2-[(2-methyl-2-propanyl)amino]-2-oxoethyl}-1H-indol-2-carboxylat [German] [ACD/IUPAC Name]
YH 239-EE
YH239-EE
[1364488-67-4] [RN]
1238697-26-1 [RN]
More...
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      Apoptosis MedChem Express HY-12287
      Apoptosis; MedChem Express HY-12287
      MDM-2, p53 MedChem Express HY-12287
      YH239-EE, ethyl ester of the free carboxylic acid compound YH239, is a potent p53-MDM2 antagonizing and apoptosis-inducing agent MedChem Express
      YH239-EE, ethyl ester of the free carboxylic acid compound YH239, is a potent p53-MDM2 antagonizing and apoptosis-inducing agent; IC50 value:; Target: MDM2/p53; YH239-EE inhibits the growth of OCI-AML-3 cells with wild type p53 by inhibiting the p53-MDM2 interaction. MedChem Express HY-12287
      YH239-EE, ethyl ester of the free carboxylic acid compound YH239, is a potent p53-MDM2 antagonizing and apoptosis-inducing agent;IC50 value:;Target: MDM2/p53YH239-EE inhibits the growth of OCI-AML-3 cells with wild type p53 by inhibiting the p53-MDM2 interaction. YH239-EE induces cell cycle arrest and causes potent cell apoptosis via activation of p53 and downstream targets in four AML cells (OCI-AML-3 and MOLM-13 with wt p53, NB4 with p53 mutation, and HL60 with p53 deletion). MedChem Express HY-12287

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.3±0.1 g/cm3
Boiling Point: 763.3±60.0 °C at 760 mmHg
Vapour Pressure: 0.0±2.6 mmHg at 25°C
Enthalpy of Vaporization: 111.2±3.0 kJ/mol
Flash Point: 415.4±32.9 °C
Index of Refraction: 1.615
Molar Refractivity: 134.1±0.3 cm3
#H bond acceptors: 7
#H bond donors: 2
#Freely Rotating Bonds: 9
#Rule of 5 Violations: 1
ACD/LogP: 4.85
ACD/LogD (pH 5.5): 4.87
ACD/BCF (pH 5.5): 2972.82
ACD/KOC (pH 5.5): 10658.35
ACD/LogD (pH 7.4): 4.87
ACD/BCF (pH 7.4): 2972.81
ACD/KOC (pH 7.4): 10658.30
Polar Surface Area: 92 Å2
Polarizability: 53.1±0.5 10-24cm3
Surface Tension: 52.9±3.0 dyne/cm
Molar Volume: 384.0±3.0 cm3

Click to predict properties on the Chemicalize site


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