ChemSpider 2D Image | AMG 925 | C26H29N7O2

AMG 925

  • Molecular FormulaC26H29N7O2
  • Average mass471.554 Da
  • Monoisotopic mass471.238281 Da
  • ChemSpider ID34237042

  • defined stereocentres - 2 of 2 defined stereocentres

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1401033-86-0 [RN]
2-Hydroxy-1-[2-{[9-(trans-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl]amino}-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]ethanon [German] [ACD/IUPAC Name]
2-Hydroxy-1-[2-{[9-(trans-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl]amino}-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]ethanone [ACD/IUPAC Name]
2-Hydroxy-1-[2-{[9-(trans-4-méthylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl]amino}-7,8-dihydro-1,6-naphtyridin-6(5H)-yl]éthanone [French] [ACD/IUPAC Name]
AMG 925
AMG-925
Ethanone, 1-[7,8-dihydro-2-[[9-(trans-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl]amino]-1,6-naphthyridin-6(5H)-yl]-2-hydroxy- [ACD/Index Name]
RB6Y814V4I
[1401033-86-0] [RN]
1-?[7,?8-?dihydro-?2-?[[9-?(trans-?4-?methylcyclohexyl)?-?9H-?pyrido[4',?3':4,?5]?pyrrolo[2,?3-?d]?pyrimidin-?2-?yl]?amino]?-?1,?6-?naphthyridin-?6(5H)?-?yl]?-?2-?hydroxy-Ethanone
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  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Chemical Class:

      An organic heterotricyclic compound that is 9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidine which is substituted by a [6-(hydroxyacetyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl]nitrilo group at position 2 and by a trans-4-methylcyclohexyl group at position 9. It is a FLT3 and CDK4 dual kinase inhibitor that has antineoplastic activity. Currently under clinical investigation in patients with relapsed or refractory acute myeloid leukemia (AML). ChEBI CHEBI:145537

    • Bio Activity:

      AMG 925 is a potent and selective dual inhibtor of CDK4/FLT3 with IC50s of 1.5 nM and 2.4 nM for CDK4 and FLT3, respectively; with IC50 of 19 nM in MOLM-13 cell. MedChem Express
      AMG 925 is a potent and selective dual inhibtor of CDK4/FLT3 with IC50s of 1.5 nM and 2.4 nM for CDK4 and FLT3, respectively; with IC50 of 19 nM in MOLM-13 cell.; IC50 value: 1.5/2.4 nM (CDK4/FLT3); Target: CDK4/FLT3; More information can be found in Patent WO 2012129344 A1; Fused tricyclic dual inhibitors of cdk 4/6 and flt3.; MedChem Express HY-15889
      AMG 925 is a potent and selective dual inhibtor of CDK4/FLT3 with IC50s of 1.5 nM and 2.4 nM for CDK4 and FLT3, respectively; with IC50 of 19 nM in MOLM-13 cell.;IC50 value: 1.5/2.4 nM (CDK4/FLT3);Target: CDK4/FLT3More information can be found in Patent WO 2012129344 A1Fused tricyclic dual inhibitors of cdk 4/6 and flt3. MedChem Express HY-15889
      CDK MedChem Express HY-15889
      CDK FLT3 MedChem Express HY-15889
      Cell Cycle/DNA Damage MedChem Express HY-15889
      Cell Cycle/DNA Damage; Protein Tyrosine Kinase/RTK; MedChem Express HY-15889

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.5±0.1 g/cm3
Boiling Point: 712.3±70.0 °C at 760 mmHg
Vapour Pressure: 0.0±2.4 mmHg at 25°C
Enthalpy of Vaporization: 109.3±3.0 kJ/mol
Flash Point: 384.6±35.7 °C
Index of Refraction: 1.766
Molar Refractivity: 131.8±0.5 cm3
#H bond acceptors: 9
#H bond donors: 2
#Freely Rotating Bonds: 4
#Rule of 5 Violations: 0
ACD/LogP: 1.67
ACD/LogD (pH 5.5): 2.55
ACD/BCF (pH 5.5): 41.63
ACD/KOC (pH 5.5): 391.15
ACD/LogD (pH 7.4): 2.93
ACD/BCF (pH 7.4): 98.51
ACD/KOC (pH 7.4): 925.45
Polar Surface Area: 109 Å2
Polarizability: 52.2±0.5 10-24cm3
Surface Tension: 63.9±7.0 dyne/cm
Molar Volume: 318.4±7.0 cm3

Click to predict properties on the Chemicalize site


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