ChemSpider 2D Image | GX7000000 | C36H45BrN4O6

GX7000000

  • Molecular FormulaC36H45BrN4O6
  • Average mass709.670 Da
  • Monoisotopic mass708.252258 Da
  • ChemSpider ID8007368

  • Double-bond stereo - Double-bond stereo

    defined stereocentres - 6 of 6 defined stereocentres

More details:

Featured data source
Natural Product Updates

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(4R,7R,10S,13S,15E,17R,19S)-7-[(2-Brom-1H-indol-3-yl)methyl]-4-(4-hydroxyphenyl)-8,10,13,15,17,19-hexamethyl-1-oxa-5,8,11-triazacyclononadec-15-en-2,6,9,12-tetron [German] [ACD/IUPAC Name]
(4R,7R,10S,13S,15E,17R,19S)-7-[(2-Bromo-1H-indol-3-yl)methyl]-4-(4-hydroxyphenyl)-8,10,13,15,17,19-hexamethyl-1-oxa-5,8,11-triazacyclononadec-15-ene-2,6,9,12-tetrone [ACD/IUPAC Name]
(4R,7R,10S,13S,15E,17R,19S)-7-[(2-Bromo-1H-indol-3-yl)méthyl]-4-(4-hydroxyphényl)-8,10,13,15,17,19-hexaméthyl-1-oxa-5,8,11-triazacyclononadéc-15-ène-2,6,9,12-tétrone [French] [ACD/IUPAC Name]
102396-24-7 [RN]
1-Oxa-5,8,11-triazacyclononadec-15-ene-2,6,9,12-tetrone, 7-[(2-bromo-1H-indol-3-yl)methyl]-4-(4-hydroxyphenyl)-8,10,13,15,17,19-hexamethyl-, (4R,7R,10S,13S,15E,17R,19S)- [ACD/Index Name]
GX7000000
Jaspamide
jasplakinolide
MFCD00873735
(+)-Jasplakinolide
More...
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Chemical Class:

      A cyclodepsipeptide isolated from <ital>Jaspis splendens</ital> and has been shown to exhibit antineoplastic activity. ChEBI CHEBI:66104
      A cyclodepsipeptide isolated from Jaspis splendens and has been shown to exhibit antineoplastic activity. It is an actin polymerization and stabilization inducer. ChEBI CHEBI:66104

    • Bio Activity:

      Actin Tocris Bioscience 2792
      Biochemicals & small molecules Hello Bio [HB3946]
      Cell permeable, non-fluorescent F-actin probe. Induces actin polymerization and stabilization. Hello Bio [HB3946]
      Cell permeable, non-fluorescent F-actin probe. Potent inducer of actin polymerization and stabilization. Competes with phallotoxins for actin binding. Antifungal and antiparasitic compound. Antiproliferative and anticancer compound. Apoptosis enhancer/inducer. Tool used for autophagy/phagocytosis research. Hello Bio [HB3946]
      Cytoskeleton and Motor Proteins Tocris Bioscience 2792
      Proteins - Other/Actin Hello Bio [HB3946]
      Rapidly stabilizes pre-formed actin filaments and inhibits their disassembly in vitro. Also induces polymerization of actin monomers into F-actin in vivo. Shown to bind to F-actin competitively with p halloidin (Cat. No. 4535) (Kd ~ 15 nM). Exhibits antifungal and antiproliferative effects (IC50 = 35 nM for antiproliferative activity in PC3 cells). Cell permeable. Tocris Bioscience 2792
      Rapidly stabilizes pre-formed actin filaments and inhibits their disassembly in vitro. Also induces polymerization of actin monomers into F-actin in vivo. Shown to bind to F-actin competitively with phalloidin (Cat. No. 4535) (Kd ~ 15 nM). Exhibits antifungal and antiproliferative effects (IC50 = 35 nM for antiproliferative activity in PC3 cells). Cell permeable. Tocris Bioscience 2792
      Stabilizes F-actin; promotes actin polymerization Tocris Bioscience 2792

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.2±0.1 g/cm3
Boiling Point: 968.3±65.0 °C at 760 mmHg
Vapour Pressure: 0.0±0.3 mmHg at 25°C
Enthalpy of Vaporization: 145.9±3.0 kJ/mol
Flash Point: 539.4±34.3 °C
Index of Refraction: 1.553
Molar Refractivity: 184.9±0.3 cm3
#H bond acceptors: 10
#H bond donors: 4
#Freely Rotating Bonds: 3
#Rule of 5 Violations: 2
ACD/LogP: 4.24
ACD/LogD (pH 5.5): 4.49
ACD/BCF (pH 5.5): 1528.22
ACD/KOC (pH 5.5): 6619.59
ACD/LogD (pH 7.4): 4.49
ACD/BCF (pH 7.4): 1520.99
ACD/KOC (pH 7.4): 6588.28
Polar Surface Area: 141 Å2
Polarizability: 73.3±0.5 10-24cm3
Surface Tension: 40.4±3.0 dyne/cm
Molar Volume: 578.0±3.0 cm3

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