ChemSpider 2D Image | MFCD06798375 | C26H33NO6

MFCD06798375

  • Molecular FormulaC26H33NO6
  • Average mass455.543 Da
  • Monoisotopic mass455.230774 Da
  • ChemSpider ID21475062

  • Double-bond stereo - Double-bond stereo

    defined stereocentres - 2 of 2 defined stereocentres

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(2Z)-2-Butendisäure --4-[(1R,2S)-3-(4-benzyl-1-piperidinyl)-1-hydroxy-2-methylpropyl]phenol (1:1) [German] [ACD/IUPAC Name]
[R-(R*,S*)]-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol maleate salt
1312991-76-6 [RN]
169274-78-6 [RN]
1-Piperidinepropanol, α-(4-hydroxyphenyl)-β-methyl-4-(phenylmethyl)-, ( αR,βS)-, (2Z)-2-butenedioate (1:1)
1-Piperidinepropanol, α-(4-hydroxyphenyl)-β-methyl-4-(phenylmethyl)-, (αR,βS)-, (2Z)-2-butenedioate (1:1) (salt) [ACD/Index Name]
4-[(1R,2S)-3-(4-Benzyl-1-piperidinyl)-1-hydroxy-2-methylpropyl]phenol (2Z)-2-butenedioate (1:1) [ACD/IUPAC Name]
4-[(1R,2S)-3-(4-Benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol (2Z)-but-2-enedioate (1:1)
Acide (2Z)-2-butènedioïque - 4-[(1R,2S)-3-(4-benzyl-1-pipéridinyl)-1-hydroxy-2-méthylpropyl]phénol (1:1) [French] [ACD/IUPAC Name]
MFCD06798375
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

PubChem Substance ID 329825761 [DBID]
  • References
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Chemical Class:

      The maleic acid salt of Ro 25-6981. It is a potent and selective antagonist of GluN2B-containing NMDA receptors. ChEBI CHEBI:180901

    • Bio Activity:

      <p>Ro 25-6981 maleate is a selective negative allosteric modulator (NAM) of GluN2B (NR2B) containing NMDARs.</p> <p>Ro 25-6981 maleate exhibits &gt;5000-fold selectivity at GluN1C-GluN2B over GluN1C-GluN2A (IC<sub>50</sub> values are 9 nM and 52 &micro;M). Ro 25-6981 maleate shows neuroprotective properties.</p> Hello Bio HB0554
      Biochemicals & small molecules/Antagonists & inhibitors Hello Bio HB0554
      Glutamate (Ionotropic) Receptors Tocris Bioscience 1594
      Ion Channels Tocris Bioscience 1594
      Ion channels/Ligand-gated ion channel/Ionotropic glutamate receptors/NMDA Hello Bio HB0554
      Ligand-gated Ion Channels Tocris Bioscience 1594
      Membrane Tranporter/Ion Channel MedChem Express HY-13993A
      Membrane Tranporter/Ion Channel; Neuronal Signaling; MedChem Express HY-13993A
      NMDA Receptor MedChem Express HY-13993A
      NR2B-selective NMDA antagonist Tocris Bioscience 1594
      Potent and selective activity-dependent blocker of NMDA receptors containing the NR2B subunit. IC50 values are 0.009 and 52 ?M for cloned receptor subunit combinations NR1C/NR2B and NR1C/NR2A respecti vely. Displays neuroprotectant effects in vivo and in vitro. Tocris Bioscience 1594
      Potent and selective activity-dependent blocker of NMDA receptors containing the NR2B subunit. IC50 values are 0.009 and 52 ?M for cloned receptor subunit combinations NR1C/NR2B and NR1C/NR2A respectively. Displays neuroprotectant effects in vivo and in vitro. Tocris Bioscience 1594
      Potent and selective activity-dependent blocker of NMDA receptors containing the NR2B subunit. IC50 values are 0.009 and 52 muM for cloned receptor subunit combinations NR1C/NR2B and NR1C/NR2A respectively. Displays neuroprotectant effects in vivo and in vitro. Tocris Bioscience 1594
      Ro 25-6981 Maleate is a potent and selective activity-dependent blocker of NMDA receptors containing the NR2B subunit. MedChem Express http://www.medchemexpress.com/mps1-in-2.html, HY-13993A
      Selective negative allosteric modulator of GluN2B (NR2B) containing NMDARs Hello Bio HB0554
      Subtype-selective NR2B antagonist Tocris Bioscience 1594

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

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