ChemSpider 2D Image | EMD 638683 | C18H18F2N2O4

EMD 638683

  • Molecular FormulaC18H18F2N2O4
  • Average mass364.343 Da
  • Monoisotopic mass364.123474 Da
  • ChemSpider ID29211905

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1181770-72-8 [RN]
2-(3,5-difluorophenyl)-N'-(2-ethyl-4-hydroxy-3-methylbenzoyl)-2-hydroxyacetohydrazide
Benzeneacetic acid, 3,5-difluoro-α-hydroxy-, 2-(2-ethyl-4-hydroxy-3-methylbenzoyl)hydrazide [ACD/Index Name]
EMD 638683
N'-[(3,5-Difluorophenyl)(hydroxy)acetyl]-2-ethyl-4-hydroxy-3-methylbenzohydrazide [ACD/IUPAC Name]
N'-[(3,5-Difluorphenyl)(hydroxy)acetyl]-2-ethyl-4-hydroxy-3-methylbenzohydrazid [German] [ACD/IUPAC Name]
N'-[2-(3,5-Difluorophényl)-2-hydroxyacétyl]-2-éthyl-4-hydroxy-3-méthylbenzohydrazide [French] [ACD/IUPAC Name]
1184940-46-2 [RN]
1184940-47-3 [RN]
EMD 638683 (R-Form);EMD-638683 (R-Form)
More...
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      EMD638683 is a potent SGK1 inhibitor with an IC50 of 3 uM. MedChem Express
      EMD638683 is a potent SGK1 inhibitor with an IC50 of 3 uM.; IC50 Value: 3 uM; Target: SGK1; The serum- and glucocorticoid-inducible kinase 1 (SGK1) is transcriptionally upregulated by mineralocorticoids and activated by insulin. MedChem Express HY-15193
      Others MedChem Express HY-15193
      SGK MedChem Express HY-15193

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.4±0.1 g/cm3
Boiling Point: 657.6±55.0 °C at 760 mmHg
Vapour Pressure: 0.0±2.1 mmHg at 25°C
Enthalpy of Vaporization: 101.7±3.0 kJ/mol
Flash Point: 351.5±31.5 °C
Index of Refraction: 1.592
Molar Refractivity: 90.4±0.3 cm3
#H bond acceptors: 6
#H bond donors: 4
#Freely Rotating Bonds: 5
#Rule of 5 Violations: 0
ACD/LogP: 2.86
ACD/LogD (pH 5.5): 2.03
ACD/BCF (pH 5.5): 20.46
ACD/KOC (pH 5.5): 301.88
ACD/LogD (pH 7.4): 2.00
ACD/BCF (pH 7.4): 18.99
ACD/KOC (pH 7.4): 280.13
Polar Surface Area: 99 Å2
Polarizability: 35.8±0.5 10-24cm3
Surface Tension: 54.0±3.0 dyne/cm
Molar Volume: 267.1±3.0 cm3

Click to predict properties on the Chemicalize site


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