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Search term: CPIDEBBXBVMQOC-UHFFFAOYSA-N (Found by InChIKey (full match))
ChemSpider 2D Image | N-{5-[2-(2-Cyano-2-propanyl)-4-pyridinyl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}-4,6-dimethoxy-5-pyrimidinecarboxamide | C20H17F3N6O3S

N-{5-[2-(2-Cyano-2-propanyl)-4-pyridinyl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}-4,6-dimethoxy-5-pyrimidinecarboxamide

  • Molecular FormulaC20H17F3N6O3S
  • Average mass478.448 Da
  • Monoisotopic mass478.103485 Da
  • ChemSpider ID129306707

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

5-Pyrimidinecarboxamide, N-[5-[2-(1-cyano-1-methylethyl)-4-pyridinyl]-4-(trifluoromethyl)-2-thiazolyl]-4,6-dimethoxy- [ACD/Index Name]
N-{5-[2-(2-Cyan-2-propanyl)-4-pyridinyl]-4-(trifluormethyl)-1,3-thiazol-2-yl}-4,6-dimethoxy-5-pyrimidincarboxamid [German] [ACD/IUPAC Name]
N-{5-[2-(2-Cyano-2-propanyl)-4-pyridinyl]-4-(trifluoromethyl)-1,3-thiazol-2-yl}-4,6-dimethoxy-5-pyrimidinecarboxamide [ACD/IUPAC Name]
N-{5-[2-(2-Cyano-2-propanyl)-4-pyridinyl]-4-(trifluorométhyl)-1,3-thiazol-2-yl}-4,6-diméthoxy-5-pyrimidinecarboxamide [French] [ACD/IUPAC Name]
2019994-90-0 [RN]
Trpvicin
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      <p>Novel, potent, subtype-selective TRPV3 inhibitor which antagonizes both the hTRPV3-WT and the pathogenic mutant hTRPV3-G573S channels (IC<sub>50</sub> values are 0.41µM and 0.22µM respectively and 0.38µM at mTRPV3). Inhibits the TRPV3 channel by stabilizing it in a closed state. Attenuates TRPV3-mediated responses to show pharmacological potential in the inhibition of itch and hair loss in mouse models.</p> Hello Bio HB9908

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.4±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.583
Molar Refractivity: 112.8±0.3 cm3
#H bond acceptors: 9
#H bond donors: 1
#Freely Rotating Bonds: 8
#Rule of 5 Violations: 0
ACD/LogP: 2.97
ACD/LogD (pH 5.5): 0.78
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 8.08
ACD/LogD (pH 7.4): 0.74
ACD/BCF (pH 7.4): 1.00
ACD/KOC (pH 7.4): 7.40
Polar Surface Area: 151 Å2
Polarizability: 44.7±0.5 10-24cm3
Surface Tension: 52.1±3.0 dyne/cm
Molar Volume: 337.5±3.0 cm3

Click to predict properties on the Chemicalize site


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