Found 1 result

Search term: NHXVGMQFCYBLTL-ZWNOBZJWSA-N (Found by InChIKey (full match))
ChemSpider 2D Image | 5-amino-N-{5-[(4R,5R)-4-amino-5-fluoroazepan-1-yl]-1-methylpyrazol-4-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide | C20H22F3N7OS

5-amino-N-{5-[(4R,5R)-4-amino-5-fluoroazepan-1-yl]-1-methylpyrazol-4-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide

  • Molecular FormulaC20H22F3N7OS
  • Average mass465.495 Da
  • Monoisotopic mass465.155853 Da
  • ChemSpider ID35308330

  • defined stereocentres - 2 of 2 defined stereocentres

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1428569-85-0 [RN]
4-Thiazolecarboxamide, 5-amino-N-[5-[(4R,5R)-4-amino-5-fluorohexahydro-1H-azepin-1-yl]-1-methyl-1H-pyrazol-4-yl]-2-(2,6-difluorophenyl)- [ACD/Index Name]
5-Amino-N-{5-[(4R,5R)-4-amino-5-fluor-1-azepanyl]-1-methyl-1H-pyrazol-4-yl}-2-(2,6-difluorphenyl)-1,3-thiazol-4-carboxamid [German] [ACD/IUPAC Name]
5-Amino-N-{5-[(4R,5R)-4-amino-5-fluoro-1-azepanyl]-1-methyl-1H-pyrazol-4-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide [ACD/IUPAC Name]
5-Amino-N-{5-[(4R,5R)-4-amino-5-fluoro-1-azépanyl]-1-méthyl-1H-pyrazol-4-yl}-2-(2,6-difluorophényl)-1,3-thiazole-4-carboxamide [French] [ACD/IUPAC Name]
5-amino-N-{5-[(4R,5R)-4-amino-5-fluoroazepan-1-yl]-1-methyl-1H-pyrazol-4-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide
5-amino-N-{5-[(4R,5R)-4-amino-5-fluoroazepan-1-yl]-1-methylpyrazol-4-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide
1428577-27-8 [RN]
5-amino-N-[5-[(4R,5R)-4-amino-5-fluoroazepan-1-yl]-1-methylpyrazol-4-yl]-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide
GDC-0339
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      GDC-0339 is a Pim kinase inhibitor with IC50 of 43.6 nM for BaF3 PIM1. MedChem Express
      GDC-0339 is a Pim kinase inhibitor with IC50 of 43.6 nM for BaF3 PIM1.; IC50 value: 43.6 nM (for BaF3 PIM1), 0.04 nM (Ki, for PIM1 LC-3K); Target: Pim; MedChem Express HY-16976
      GDC-0339 is a Pim kinase inhibitor with IC50 of 43.6 nM for BaF3 PIM1.;IC50 value: 43.6 nM (for BaF3 PIM1), 0.04 nM (Ki, for PIM1 LC-3K);Target: Pim MedChem Express HY-16976
      JAK/STAT Signaling MedChem Express HY-16976
      JAK/STAT Signaling; MedChem Express HY-16976
      Pim MedChem Express HY-16976

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.6±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.715
Molar Refractivity: 113.5±0.5 cm3
#H bond acceptors: 8
#H bond donors: 5
#Freely Rotating Bonds: 4
#Rule of 5 Violations: 1
ACD/LogP: 0.43
ACD/LogD (pH 5.5): -2.56
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 1.00
ACD/LogD (pH 7.4): -1.61
ACD/BCF (pH 7.4): 1.00
ACD/KOC (pH 7.4): 1.00
Polar Surface Area: 143 Å2
Polarizability: 45.0±0.5 10-24cm3
Surface Tension: 57.9±7.0 dyne/cm
Molar Volume: 289.1±7.0 cm3

Click to predict properties on the Chemicalize site


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