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- Effective co-delivery of nutlin-3a and p53 genes via core–shell microparticles for disruption of MDM2–p53 interaction and reactivation of p53 in hepatocellular carcinoma. Pooya Davoodi, Madapusi P. Srinivasan, Chi-Hwa Wang
, J. Mater. Chem. B
, 2017
, 5
, 5816
- Dual-channel surface plasmon resonance monitoring of intracellular levels of the p53-MDM2 complex and caspase-3 induced by MDM2 antagonist Nutlin-3. Ling Wu, Yuqing Hu, Yuhan He, Yonghong Xia, Hanwen Lu, Zhong Cao, Xinyao Yi, Jianxiu Wang
, Analyst
, 2019
, 144
, 3959
- Solid-state nanopore analysis on conformation change of p53TAD–MDM2 fusion protein induced by protein–protein interaction. Hongsik Chae, Dong-Kyu Kwak, Mi-Kyung Lee, Seung-Wook Chi, Ki-Bum Kim
, Nanoscale
, 2018
, 10
, 17227
- Energetics of a protein disorder–order transition in small molecule recognition. Cesar Mendoza-Martinez, Michail Papadourakis, Salomé Llabrés, Arun A. Gupta, Paul N. Barlow, Julien Michel
, Chem. Sci.
, 2022
, 13
, 5220
- The hydrophobically-tagged MDM2–p53 interaction inhibitor Nutlin-3a-HT is more potent against tumor cells than Nutlin-3a. Florian Nietzold, Stefan Rubner, Thorsten Berg
, Chem. Commun.
, 2019
, 55
, 14351
- The facile and visualizable identification of broad-spectrum inhibitors of MDM2/p53 using co-expressed protein complexes. Yang Yang, Zhiqiang Dong, Hongze Hu, Junhui Peng, Yaping Sheng, Yang Tong, Siming Yuan, Zigang Li, Jiaxiang Yang, Thomas Wells, Yun Qu, Nicholas P. Farrell, Yangzhong Liu
, Analyst
, 2019
, 144
, 3773
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Catalytic, enantioselective synthesis of stilbenecis-diamines: A concise preparation of (−)-Nutlin-3, a potent p53/MDM2 inhibitor. Tyler A. Davis, Jeffrey N. Johnston
, Chem. Sci.
, 2011
, 2
, 1076
- A highly sensitive fluorescent light-up probe for real-time detection of the endogenous protein target and its antagonism in live cells. Junlong Geng, Walter L. Goh, Chongjing Zhang, David P. Lane, Bin Liu, Farid Ghadessy, Yen Nee Tan
, J. Mater. Chem. B
, 2015
, 3
, 5933
- Rapid identification of dual p53-MDM2/MDMX interaction inhibitors through virtual screening and hit-based substructure search. Si Chen, Xiang Li, Weirong Yuan, Yan Zou, Zhongwu Guo, Yifeng Chai, Wuyuan Lu
, RSC Adv.
, 2017
, 7
, 9989
- Recent applications of covalent chemistries in protein–protein interaction inhibitors. Alexandria M. Chan, Christopher C. Goodis, Elie G. Pommier, Steven Fletcher
, RSC Med. Chem.
, 2022
, 13
, 921