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Design, synthesis and biological evaluation of new molecules inhibiting epidermal growth factor receptor threonine790
→ methionine790 mutant . Shilin Xu, Lianwen Zhang, Shaohua Chang, Jinfeng Luo, Xiaoyun Lu, Zhengchao Tu, Yingxue Liu, Zhang zhang, Yong Xu, Xiaomei Ren, Ke Ding
, Med. Chem. Commun.
, 2012
, 3
, 1155
Insights into fourth generation selective inhibitors of (C797S) EGFR mutation combating non-small cell lung cancer resistance: a critical review . Mostafa A. Mansour, Asmaa M. AboulMagd, Samar H. Abbas, Hamdy M. Abdel-Rahman, Mohamed Abdel-Aziz
, RSC Adv.
, 2023
, 13
, 18825
L718Q mutant EGFR escapes covalent inhibition by stabilizing a non-reactive conformation of the lung cancer drug osimertinib . D. Callegari, K. E. Ranaghan, C. J. Woods, R. Minari, M. Tiseo, M. Mor, A. J. Mulholland, A. Lodola
, Chem. Sci.
, 2018
, 9
, 2740
C5-substituted pyrido[2,3-d ]pyrimidin-7-ones as highly specific kinase inhibitors targeting the clinical resistance-related EGFRT790M mutant . Tianfeng Xu, Ting Peng, Xiaomei Ren, Lianwen Zhang, Lei Yu, Jinfeng Luo, Zhang Zhang, Zhengchao Tu, Linjiang Tong, Zhaoru Huang, Xiaoyun Lu, Meiyu Geng, Hua Xie, Jian Ding, Ke Ding
, Med. Chem. Commun.
, 2015
, 6
, 1693
New pyrimidine-5-carbonitrile derivatives as EGFR inhibitors with anticancer and apoptotic activities: design, molecular modeling and synthesis . Ibrahim A. Osman, Rezk R. Ayyad, Hazem A. Mahdy
, New J. Chem.
, 2022
, 46
, 11812
Anticancer potential of some imidazole and fused imidazole derivatives: exploring the mechanism via epidermal growth factor receptor (EGFR) inhibition . Sourav Kalra, Gaurav Joshi, Manvendra Kumar, Sahil Arora, Harsimrat Kaur, Sandeep Singh, Anjana Munshi, Raj Kumar
, RSC Med. Chem.
, 2020
, 11
, 923
Inhibition of osimertinib-resistant epidermal growth factor receptor EGFR-T790M/C797S . Jonas Lategahn, Marina Keul, Philip Klövekorn, Hannah L. Tumbrink, Janina Niggenaber, Matthias P. Müller, Luke Hodson, Maren Flaßhoff, Julia Hardick, Tobias Grabe, Julian Engel, Carsten Schultz-Fademrecht, Matthias Baumann, Julia Ketzer, Thomas Mühlenberg, Wolf Hiller, Georgia Günther, Anke Unger, Heiko Müller, Alena Heimsoeth, Christopher Golz, Bernhard Blank-Landeshammer, Laxmikanth Kollipara, René P. Zahedi, Carsten Strohmann, Jan G. Hengstler, Willem A. L. van Otterlo, Sebastian Bauer, Daniel Rauh
, Chem. Sci.
, 2019
, 10
, 10789
Anticancer evaluations of iodoquinazoline substituted with allyl and/or benzyl as dual inhibitors of EGFRWT and EGFRT790M : design, synthesis, ADMET and molecular docking . Ahmed K. B. Aljohani, Khaled El-Adl, Basmah Almohaywi, Omar M. Alatawi, Marwa Alsulaimany, Ahmed El-morsy, Sara A. Almadani, Hussam Y. Alharbi, Majed S. Aljohani, Felemban Athary Abdulhaleem M, Hanan E. M. Osman, Samy Mohamady
, RSC Adv.
, 2024
, 14
, 7964
Quinoline–hydrazone hybrids as dual mutant EGFR inhibitors with promising metallic nanoparticle loading: rationalized design, synthesis, biological investigation and computational studies . Ranza Elrayess, Khaled M. Darwish, Mohamed S. Nafie, Gharieb S. El-Sayyed, Mohamed M. Said, Asmaa S. A. Yassen
, New J. Chem.
, 2022
, 46
, 18207