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Structure-based virtual screening and ADME/T-based profiling for low molecular weight chemical starting points as p21-activated kinase 4 inhibitors . Ruijuan Li, Xiaolin Su, Zheng Chen, Wanxu Huang, Yali Wang, Kaibo Wang, Bin Lin, Jian Wang, Maosheng Cheng
, RSC Adv.
, 2015
, 5
, 23202
Design, synthesis and biological evaluation of 1-phenanthryl-tetrahydroisoquinoline derivatives as novel p21-activated kinase 4 (PAK4) inhibitors . Shuai Song, Xiaodong Li, Jing Guo, Chenzhou Hao, Yan Feng, Bingyu Guo, Tongchao Liu, Qiaoling Zhang, Zhen Zhang, Ruijuan Li, Jian Wang, Bin Lin, Feng Li, Dongmei Zhao, Maosheng Cheng
, Org. Biomol. Chem.
, 2015
, 13
, 3803
Advanced approaches of developing targeted covalent drugs . Conghao Gai, Suzannah J. Harnor, Shihao Zhang, CĂ©line Cano, Chunlin Zhuang, Qingjie Zhao
, RSC Med. Chem.
, 2022
, 13
, 1460
Molecular dynamics simulation and QM/MM calculation reveal the selectivity mechanism of type I 1/2 kinase inhibitors: the effect of intramolecular H-bonds and conformational restriction for improved selectivity . Hanxun Wang, Zisen Gao, Peilu Song, Baichun Hu, Jian Wang, Maosheng Cheng
, Phys. Chem. Chem. Phys.
, 2019
, 21
, 24147
Recent developments in anticancer kinase inhibitors based on the pyrazolo[3,4-d ]pyrimidine scaffold . Daniel J. Baillache, Asier Unciti-Broceta
, RSC Med. Chem.
, 2020
, 11
, 1112
Advances in the 1-phenanthryl-tetrahydroisoquinoline series of PAK4 inhibitors: potent agents restrain tumor cell growth and invasion . Chenzhou Hao, Xiaodong Li, Shuai Song, Bingyu Guo, Jing Guo, Jian Zhang, Qiaoling Zhang, Wanxu Huang, Jian Wang, Bin Lin, Maosheng Cheng, Feng Li, Dongmei Zhao
, Org. Biomol. Chem.
, 2016
, 14
, 7676
Identification and optimisation of 7-azaindole PAK1 inhibitors with improved potency and kinase selectivity . William McCoull, Edward J. Hennessy, Kevin Blades, Matthew R. Box, Claudio Chuaqui, James E. Dowling, Christopher D. Davies, Andrew D. Ferguson, Frederick W. Goldberg, Nicholas J. Howe, Paul D. Kemmitt, Gillian M. Lamont, Katrina Madden, Claire McWhirter, Jeffrey G. Varnes, Richard A. Ward, Jason D. Williams, Bin Yang
, Med. Chem. Commun.
, 2014
, 5
, 1533