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- Synthesis of a novel C2/C2′-exo unsaturated pyrrolobenzodiazepine cross-linking agent with remarkable DNA binding affinity and cytotoxicity. Stephen J. Gregson, Philip W. Howard, David E. Thurston, Terence C. Jenkins, Lloyd R. Kelland
, Chem. Commun.
, 1999
, 797
- Effect of microwave irradiation on covalent ligand–DNA interactions. Khondaker M. Rahman, David E. Thurston
, Chem. Commun.
, 2009
, 2875
- Natural products from thioester reductase containing biosynthetic pathways. Michael W. Mullowney, Ryan A. McClure, Matthew T. Robey, Neil L. Kelleher, Regan J. Thomson
, Nat. Prod. Rep.
, 2018
, 35
, 847
- Inter- and intrastrand DNA crosslinks by 2-fluoro-substituted pyrrolobenzodiazepine dimers: stability, stereochemistry and drug orientation. Jenny Seifert, Soheil Pezeshki, Ahmed Kamal, Klaus Weisz
, Org. Biomol. Chem.
, 2012
, 10
, 6850
- Effect of hairpin loop structure on reactivity, sequence preference and adduct orientation of a DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumour agent . David E. Thurston, Higia Vassoler, Paul J. M. Jackson, Colin H. James, Khondaker M. Rahman
, Org. Biomol. Chem.
, 2015
, 13
, 4031
- Mechanistic insight into the repair of C8-linked pyrrolobenzodiazepine monomer-mediated DNA damage. Asha Mary Joseph, Kazi Nahar, Saheli Daw, Md. Mahbub Hasan, Rebecca Lo, Tung B. K. Le, Khondaker Miraz Rahman, Anjana Badrinarayanan
, RSC Med. Chem.
, 2022
, 13
, 1621
- Synthesis of novel non-cross-linking
pyrrolobenzodiazepines with remarkable DNA binding affinity and potent
antitumour activity. Ahmed Kamal, N. Laxman, G. Ramesh, K. Neelima, Anand K. Kondapi
, Chem. Commun.
, 2001
, 437
- Synthesis of a novel C2-aryl substituted 1,2-unsaturated pyrrolobenzodiazepine. Gyoung-Dong Kang, Philip W. Howard, David E. Thurston
, Chem. Commun.
, 2003
, 1688
- Observation of the reversibility of a covalent pyrrolobenzodiazepine (PBD) DNA adduct by HPLC/MS and CD spectroscopy. Khondaker M. Rahman, Colin H. James, David E. Thurston
, Org. Biomol. Chem.
, 2011
, 9
, 1632
- A rapid screen for molecules that form duplex to duplex crosslinks in DNA. María J. Marín, Benjamin D. Rackham, Andrew N. Round, Lesley A. Howell, David A. Russell, Mark Searcey
, Chem. Commun.
, 2013
, 49
, 9113