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11The facile and efficient synthesis of 8-chloroadenosine 3u2032,5u2032-cyclic monophosphate by phosphorylative cyclization of 8-chloroadenosine and its characterization by1H and13C NMR spectroscopy, Archives of Pharmacal Research 8-Chloro-cAMP Serves as a Prodrug for the RNA Directed Nucleoside Analog, 8-Chloro-Adenosine, Acute Leukemias IX 8-Cl-adenosine is an active metabolite of 8-Cl-cAMP responsible for its in vitro antiproliferative effects on CHO mutants hypersensitive to cytostatic drugs, Cancer Chemotherapy and Pharmacology E2F1-mediated DNA damage is implicated in 8-Cl-adenosine-induced chromosome missegregation and apoptosis in human lung cancer H1299 cells, Molecular and Cellular Biochemistry A unique RNA-directed nucleoside analog is cytotoxic to breast cancer cells and depletes cyclin E levels, Breast Cancer Research and Treatment ATP directed agent, 8-chloro-adenosine, induces AMP activated protein kinase activity, leading to autophagic cell death in breast cancer cells, Journal of Hematology & Oncology E2F1 enhances 8-Chloro-adenosine-induced G2/M arrest and apoptosis in A549 and H1299 lung cancer cells, Biochemistry (Moscow) In briefu2026, Inpharma Weekly